MTNR1B, melatonin receptor 1B, 4544

N. diseases: 80; N. variants: 7
Disease: Hyperglycemia ×
Source: BEFREE ×
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0020456
Disease: Hyperglycemia
Hyperglycemia 		0.040 Biomarker disease BEFREE Melatonin receptor 1B gene associated with hyperglycemia in bipolar disorder. 26991397 2016
CUI: C0020456
Disease: Hyperglycemia
Hyperglycemia 		0.040 GeneticVariation disease BEFREE The second cluster (MTNR1B, GCK) featured risk alleles associated with reduced insulin secretion and fasting hyperglycemia. 24296717 2014
CUI: C0020456
Disease: Hyperglycemia
Hyperglycemia 		0.040 GeneticVariation disease BEFREE Common variants of MTNR1B, G6PC2 and GCK are associated with elevated FPG and impaired insulin secretion, both individually and jointly, suggesting that these risk alleles may precipitate or perpetuate hyperglycemia in predisposed individuals. 20628598 2010
CUI: C0020456
Disease: Hyperglycemia
Hyperglycemia 		0.040 GeneticVariation disease BEFREE The aims of this study were to evaluate whether nonsynonymous variants in MTNR1B associate with monogenic forms of hyperglycemia, type 2 diabetes, or related metabolic traits. 20200315 2010