MTNR1B, melatonin receptor 1B, 4544

N. diseases: 80; N. variants: 7
Disease: Impaired insulin secretion ×
Source: BEFREE ×
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0948379
Disease: Impaired insulin secretion
Impaired insulin secretion 		0.020 GeneticVariation disease BEFREE Common variants of MTNR1B, G6PC2 and GCK are associated with elevated FPG and impaired insulin secretion, both individually and jointly, suggesting that these risk alleles may precipitate or perpetuate hyperglycemia in predisposed individuals. 20628598 2010
CUI: C0948379
Disease: Impaired insulin secretion
Impaired insulin secretion 		0.020 GeneticVariation disease BEFREE Recently, three groups independently reported that variation in MTNR1B, the gene encoding melatonin receptor 1B, was associated with an increased risk of type 2 diabetes, increased fasting plasma glucose and impaired insulin secretion in populations of European ancestry. 19241057 2009