|
Coronary heart disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
<b>Background:</b> We performed the present study to better elucidate the correlations of methylenetetrahydrofolate reductase (<i>MTHFR</i>) and methionine synthase reductase (<i>MTRR</i>) gene polymorphisms with the risk of congenital heart diseases (CHD).<b>Methods:</b> Eligible articles were searched in PubMed, Medline, Embase and CNKI.
|
30333252 |
2018 |
|
Coronary heart disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
The methylenetetrahydrofolate reductase (MTHFR) and methionine synthase reductase (MTRR) genes are two of the most important candidate genes for fetal CHD.
|
28758112 |
2017 |
|
Coronary heart disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
So A66G and C524T polymorphisms of MTRR gene are associated with increased risk of acyanotic CHDs.
|
28778621 |
2017 |
|
Coronary heart disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
On multivariate analysis, the risk factors noted for CHD were presence of MTHFR C677→︀T among children and their mothers and MTRR A66→︀G among mothers.
|
28876333 |
2017 |
|
Coronary heart disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Previous studies have focused on the coding region of genes involved in one-carbon metabolism, but recent research demonstrates that an allelic change in a non-coding region of MTRR (rs326119) increases the risk of CHD.
|
26045171 |
2015 |
|
Coronary heart disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In summary, the metaanalysis demonstrated that MTRR A66G polymorphism is a risk factor for CHDs.
|
24913415 |
2014 |
|
Coronary heart disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Evidence is mounting for the association between MTRR A66G (rs1801394)/MTR A2756G (rs1805087) and the CHD risk, but results are controversial.
|
24595101 |
2014 |
|
Coronary heart disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The results suggested that the MTRR A66G polymorphism was not associated with risk of CHD for Europeans (AA vs. GG: OR [95% CI]=1.07 [0.59-1.94], p(z)(-test)=0.831, p(heterogeneity)<0.01).
|
21780915 |
2012 |
|
Coronary heart disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We have demonstrated that the MTRR c.56+781 A>C variant is an important genetic marker for increased CHD risk because this variant results in functionally reduced MTRR expression at the transcriptional level.
|
22179537 |
2012 |
|
Coronary heart disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, MTRR A66G and C524T polymorphisms are associated with increased risk of CHDs.
|
22057956 |
2011 |
|
Coronary heart disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In a group of 121 case families (mother, father, and proband with DS and AVSD) and 122 control families (mother, father, and proband with DS and no CHD), tag SNPs were genotyped in and around five folate pathway genes: 5,10-methylenetetrahyrdofolate reductase (MTHFR), methionine synthase (MTR), methionine synthase reductase (MTRR), cystathionine beta-synthase (CBS), and the reduced folate carrier (SLC19A1, RFC1).
|
20718043 |
2010 |
|
Coronary heart disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The MTRR and TC genotypes did not significantly affect CHD risk.
|
18226574 |
2008 |
|
Coronary heart disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We studied the influence of the MTRR 66A>G polymorphism on CHD risk.
|
17087642 |
2006 |
|
Coronary heart disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Methylenetetrahydrofolate reductase (MTHFR) 677C>T and methionine synthase reductase (MTRR) 66A>G polymorphisms: association with serum homocysteine and angiographic coronary artery disease in the era of flour products fortified with folic acid.
|
12801615 |
2003 |