|
Neural Tube Defects
|
0.100 |
GeneticVariation
|
group |
BEFREE |
MTHFR (C677T, A1298C) and MTRR A66G polymorphisms were found to be protector factors for NTD fetuses in the mother group.
|
31238314 |
2019 |
|
Neural Tube Defects
|
0.100 |
AlteredExpression
|
group |
BEFREE |
A much-reduced expression of MTHFR (p < 0.01) and an abnormally high expression of methionine synthase reductase (p < 0.001) were observed in the NTD group.
|
30941645 |
2019 |
|
Neural Tube Defects
|
0.100 |
GeneticVariation
|
group |
BEFREE |
For rs1801394 within MTRR, children carrying allele G and genotype GG had a higher NTDs risk (OR=1.533, 95%CI=1.102~2.188; OR=2.355, 95%CI=1.044~5.312, respectively).
|
29392422 |
2018 |
|
Neural Tube Defects
|
0.100 |
GeneticVariation
|
group |
BEFREE |
The further meta-analysis enhance that MTRR 66A>G was connected with the susceptibility of NTDs widely.
|
26334892 |
2015 |
|
Neural Tube Defects
|
0.100 |
GeneticVariation
|
group |
BEFREE |
In conclusion, present meta-analysis supports that the maternal MTHFR C677T and MTRR A66G are polymorphisms contributory to risk for NTD.
|
25005003 |
2015 |
|
Neural Tube Defects
|
0.100 |
GeneticVariation
|
group |
BEFREE |
The present meta-analysis indicated that MTRR A66G polymorphism, but not MTR A2756G, is significantly associated with maternal risk for NTDs in Caucasians.
|
23266814 |
2013 |
|
Neural Tube Defects
|
0.100 |
GeneticVariation
|
group |
BEFREE |
However, we found no significant effects of MTHFR A1298C, MTR A2756G, MTRR A66G in risk of NTDs in dominant, recessive or in allelic models.
|
23593147 |
2013 |
|
Neural Tube Defects
|
0.100 |
Biomarker
|
group |
BEFREE |
Methionine synthase (MTR) and MTR reductase (MTRR) genes have been considered to be implicated in the development of neural tube defects (NTDs).
|
23425389 |
2013 |
|
Neural Tube Defects
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Both paternal and maternal GCP II T-variant alleles were found to interact with MTHFR 677T- and MTRR G-variant alleles in increasing the risk for NTD.
|
20047525 |
2010 |
|
Neural Tube Defects
|
0.100 |
GeneticVariation
|
group |
BEFREE |
An homozygous state for the MTRR polymorphism was diagnosed in the mother, identifying a clinical risk for NTD.
|
17688469 |
2007 |
|
Neural Tube Defects
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Meta-analyses were conducted to set the results of the case-control study in the context of eligible literature on the relation between the MTRR 66A>G variant and NTD risk.
|
17024475 |
2006 |
|
Neural Tube Defects
|
0.100 |
GeneticVariation
|
group |
BEFREE |
We studied the MTRR polymorphisms I22M (66A-->G), S175L (524C-->T), and K350R (1049A-->G) as potential NTD risk factors in a large homogeneous Irish NTD population.
|
15979034 |
2005 |
|
Neural Tube Defects
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Maternal-fetal interaction was also detected when offspring carried the MTHFR 677C-->T variant and mothers carried the MTRR 66A-->G variant, resulting in a significantly elevated risk of NTD.
|
15060097 |
2004 |
|
Neural Tube Defects
|
0.100 |
GeneticVariation
|
group |
BEFREE |
According to the results of this study, the genetic predisposition to NTD can be correlated with the 677TT genotype in the MTHFR gene, 677CT/1298AC haplotype (the MTHFR gene), 2756G allele in the MTR gene, 66AG variant and minisatellite sequence with 5 or 10 repeats in intron 6 of the MTRR gene.
|
15306729 |
2004 |
|
Neural Tube Defects
|
0.100 |
GeneticVariation
|
group |
LHGDN |
Results of screening mutations 2756A-->G and 66A-->G in MTR and MTRR genes respectively show that are might have an effect on NTDs incidence among the examined population.
|
12810988 |
2003 |
|
Neural Tube Defects
|
0.100 |
Biomarker
|
group |
BEFREE |
Our results indicate that MTRR and MTR genes may interact to increase the infants' NTD risks.
|
12649067 |
2003 |
|
Neural Tube Defects
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Transcobalamin and methionine synthase reductase mutated polymorphisms aggravate the risk of neural tube defects in humans.
|
12812837 |
2003 |
|
Neural Tube Defects
|
0.100 |
AlteredExpression
|
group |
BEFREE |
MTRR, combined with a low level of vitamin B12, increases the risk of NTD and of having a child with NTD in Canada, while TCN 776 GG and MTRR 66 GG mutated genotypes associated with the MTHFR 677 CC wild-type are predictors of NTD cases in Sicily.
|
14656028 |
2003 |