|
Carcinoma
|
0.100 |
AlteredExpression
|
group |
BEFREE |
MUC1-C is an oncogenic effector of the cancer cell epigenome that is overexpressed in diverse carcinomas.
|
31435022 |
2019 |
|
Carcinoma
|
0.100 |
Biomarker
|
group |
BEFREE |
Mucin 1 (MUC1) is a heterodimeric protein that is aberrantly overexpressed on the surface of diverse human carcinomas and is an attractive target for the development of mAb-based therapeutics.
|
29925694 |
2018 |
|
Carcinoma
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Receiver operating characteristic curve analysis showed that WFA-sialylated MUC1 was superior to carbohydrate antigen 19-9 (CA19-9) and carcinoembryonic antigen (CEA) for the diagnosis of benign biliary tract diseases, BTC, and IhCC, as well as for stage I and II carcinomas.
|
27358229 |
2017 |
|
Carcinoma
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The transmembrane MUC1 C-terminal subunit (MUC1-C) signals stress to the interior of the epithelial cell and, when overexpressed as in most carcinomas, functions as an oncoprotein.
|
28302417 |
2017 |
|
Carcinoma
|
0.100 |
Biomarker
|
group |
BEFREE |
Mucin 1 (MUC-1), a glycoprotein over-expressed on most malignant epithelial cell surfaces, such as colorectal, lung, prostate, pancreatic, ovarian, and bladder carcinomas, has been confirmed as a useful biomarker for the diagnosis of early cancers.
|
28107977 |
2017 |
|
Carcinoma
|
0.100 |
AlteredExpression
|
group |
BEFREE |
MUC1 is abnormally overexpressed in numerous carcinomas and associated with poor prognosis.
|
28796259 |
2017 |
|
Carcinoma
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The oncogenic MUC1-C protein is aberrantly overexpressed in diverse carcinomas; however, there is no known link between MUC1-C and DNA methylation.
|
27212035 |
2016 |
|
Carcinoma
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The results indicate that HSP90 inhibitor therapies in colon carcinomas could generate resistance and increase metastatic potential that might mediated by upregulation of MUC1 expression.
|
26872308 |
2016 |
|
Carcinoma
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The oncogenic MUC1-C transmembrane protein is aberrantly overexpressed in lung and other carcinomas; however, there is no known association between MUC1-C and the LIN28B→let-7 pathway.
|
25368430 |
2015 |
|
Carcinoma
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Emerging evidence provides support for the oncogenic role of MUC1 in gastrointestinal carcinomas and relates its expression to an invasive phenotype.
|
26436698 |
2015 |
|
Carcinoma
|
0.100 |
Biomarker
|
group |
BEFREE |
In summary, IHC labeling for PAX8, Cam5.2, CD10, and RCC marker antigen supports classification of the t(6;11) RCC as carcinomas despite frequent negativity for broad-spectrum cytokeratins and EMA.
|
24618616 |
2014 |
|
Carcinoma
|
0.100 |
AlteredExpression
|
group |
BEFREE |
In this study, in renal carcinoma, we demonstrate that (i) MUC1 and SNAIL were overexpressed in human sarcomatoid carcinomas, (ii) SNAIL increased indirectly MUC1 expression, (iii) MUC1 overexpression induced EMT, (iv) MUC1 C-terminal domain (MUC1-C) and β-catenin increased SNAIL transcriptional activity by interaction with its promoter and (v) blocking MUC1-C nuclear localization decreased Wnt/β-catenin signaling pathway activation and SNAIL expression.
|
24384091 |
2014 |
|
Carcinoma
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Mucin 1 (MUC1), a tumor-associated antigen, is a transmembrane glycoprotein expressed by normal epithelial cells and overexpressed by carcinomas of epithelial origin.
|
25128064 |
2014 |
|
Carcinoma
|
0.100 |
Biomarker
|
group |
BEFREE |
This study demonstrates that ALKBH2 is an upstream molecule of the oncoprotein, MUC1, and regulates cell cycle and EMT, resulting in progression of urothelial carcinomas.
|
23279696 |
2013 |
|
Carcinoma
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The MUC1 heterodimeric protein is aberrantly overexpressed in diverse human carcinomas and contributes to the malignant phenotype.
|
22200620 |
2012 |
|
Carcinoma
|
0.100 |
Biomarker
|
group |
BEFREE |
PANVAC consists of rV, rF-CEA-MUC1-TRICOM; the expression of the two pan-carcinoma transgenes CEA and MUC-1 renders PANVAC vaccination applicable for therapeutic applications for a range of human carcinomas.
|
22595052 |
2012 |
|
Carcinoma
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Aberrant expression of KL-6/MUC1 mucin has been proven to be associated with poorer tumor behavior in many carcinomas.
|
21617869 |
2011 |
|
Carcinoma
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Mucin 1 (MUC1) is a heterodimeric glycoprotein that is aberrantly overexpressed by human breast and other carcinomas.
|
22140559 |
2011 |
|
Carcinoma
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Mucin 1 (MUC1), a tumor-associated antigen, is a transmembrane glycoprotein expressed by normal epithelial cells and overexpressed by carcinomas of epithelial origin.
|
20876819 |
2010 |
|
Carcinoma
|
0.100 |
Biomarker
|
group |
BEFREE |
Total RNA was isolated from 18 lung carcinomas with positive carcinoembryonic antigen (CEA) and mucin-1 (MUC1) staining, as identified by immunohistochemistry.
|
19811429 |
2009 |
|
Carcinoma
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The MUC1 oncoprotein is aberrantly overexpressed by most human carcinomas and blocks oxidative stress-induced death.
|
19424588 |
2009 |
|
Carcinoma
|
0.100 |
Biomarker
|
group |
BEFREE |
Mice transgenic for MUC1 (mucin 1) and polyomavirus middle T (PyMT) develop mammary carcinomas within 15 weeks with 100% penetrance.
|
19734944 |
2009 |
|
Carcinoma
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Both fibronectin and MUC1 were differentially expressed in follicular adenomas and follicular carcinomas, and fibronectin expression differed in papillary carcinomas compared with the other lesions.
|
18094649 |
2008 |
|
Carcinoma
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The MUC1 heterodimeric protein is aberrantly overexpressed in diverse human carcinomas.
|
18089786 |
2007 |
|
Carcinoma
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The MUC1 heterodimeric transmembrane protein is aberrantly overexpressed by most human carcinomas.
|
17500061 |
2007 |