MUC1, mucin 1, cell surface associated, 4582

N. diseases: 552; N. variants: 18
Disease: Malignant tumor of colon ×
Source: BEFREE ×
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon 		0.100 AlteredExpression disease BEFREE Crosstalk between colon cells and macrophages increases ST6GALNAC1 and MUC1-sTn expression in ulcerative colitis and colitis-associated colon cancer. 31831633 2020
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon 		0.100 Biomarker disease BEFREE We previously reported that in a colon cancer prevention trial of a MUC1 vaccine tested in individuals at increased risk for colon cancer, those who did not mount immune response to the vaccine had higher pre-vaccination levels of circulating MDSC compared to those who did. 31275327 2019
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon 		0.100 Biomarker disease BEFREE An orthotopic murine model of colon cancer expressing human uMUC1 peptide (MC38 MUC1) was created along with the control model devoid of the antigen (MC38 neo). 30793239 2019
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon 		0.100 Biomarker disease BEFREE In multivariate analysis, CA19.9 (p = 0.025), CK1 (p < 0.001) and MUC1 (p = 0.009) were significant independent predictors of colon cancer. 29734875 2018
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon 		0.100 AlteredExpression disease BEFREE MUC1 is a transmembrane mucin that can promote cancer progression, and its upregulation correlates with a worse prognosis in colon cancer. 28717171 2017
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon 		0.100 AlteredExpression disease BEFREE In the present study, we first screened the colon cancer cell lines with high expression of Muc1 by western blot analysis. 24410135 2014
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon 		0.100 Biomarker disease BEFREE CTL induced by LV MUC1 DCs potently and specifically lysed the HLA-A2+, MUC1+colon cancer cell line HCT-116. 22393946 2011
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon 		0.100 AlteredExpression disease BEFREE We studied the human tumor antigen MUC1 which is abnormally expressed in colon cancers and also in inflammatory bowel disease (IBD) that gives rise to colitis-associated colon cancer (CACC). 20332301 2010
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon 		0.100 Biomarker disease BEFREE We analyzed the surgical specimens of 29 patients with colon cancer by an immunohistochemical staining method and demonstrated the co-localization of macrophages, and the expression of IL-6, CD68, and MUC1 in colon cancer patients. 19201396 2009
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon 		0.100 Biomarker disease BEFREE We report that IL-10(-/-) mice, a widely accepted mouse model of IBD, crossed to human MUC1-transgenic mice, develop MUC1(+) IBD characterized by an earlier age of onset, higher inflammation scores, and a much higher incidence and number of colon cancers compared with IL-10(-/-) mice. 17617560 2007
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon 		0.100 AlteredExpression disease BEFREE Mucin-1 expression was analyzed in a variety of colon cancer cell lines. 12530077 2003
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon 		0.100 AlteredExpression disease BEFREE MUC2 or MUC3 mRNA levels were increased in colloid colon cancer compared with normal colon, however in well- and moderately well-differentiated colon cancers MUC1, 2 and 3 mRNA levels were decreased. 7678777 1993