MUC1, mucin 1, cell surface associated, 4582

N. diseases: 552; N. variants: 18
Disease: Patent ductus arteriosus ×
Source: BEFREE ×
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0013274
Disease: Patent ductus arteriosus
Patent ductus arteriosus 		0.070 AlteredExpression disease BEFREE Similarly, in the spontaneous model of PDA that expresses human MUC1, the combination treatment stalled the progression of pancreatic intraepithelial pre-neoplastic (PanIN) lesion to adenocarcinoma. 31114758 2019
CUI: C0013274
Disease: Patent ductus arteriosus
Patent ductus arteriosus 		0.070 Biomarker disease BEFREE Poly lactic-co-glycolic acid nanoparticles (PLGA NPs) conjugated to a tumor specific MUC1 antibody, TAB004, was used as a nanocarrier for targeted delivery into human PDA cell lines in vitro and in PDA tumors in vivo. 29685122 2018
CUI: C0013274
Disease: Patent ductus arteriosus
Patent ductus arteriosus 		0.070 AlteredExpression disease BEFREE MUC1 is a tumor-associated antigen (tMUC1) expressed on 80% of PDA. 29462213 2018
CUI: C0013274
Disease: Patent ductus arteriosus
Patent ductus arteriosus 		0.070 AlteredExpression disease BEFREE We hypothesize that high levels of MUC1 in PDA may be partly responsible for the TGF-β functional switch during oncogenesis. 29467938 2018
CUI: C0013274
Disease: Patent ductus arteriosus
Patent ductus arteriosus 		0.070 Biomarker disease BEFREE Matched primary and metastatic tumor lesions from clinical specimens revealed similar MUC1 IHC labeling patterns, and a tissue microarray of human PDA biopsies revealed increased immunolabeling with a combination of MUC1 and mesothelin (MSLN) antibodies, compared with either antibody alone. 25336517 2015
CUI: C0013274
Disease: Patent ductus arteriosus
Patent ductus arteriosus 		0.070 Biomarker disease BEFREE MUC1(high) PDA patients also express high levels of cyclooxygenase 2 (COX-2) and show poor prognosis. 26035123 2015
CUI: C0013274
Disease: Patent ductus arteriosus
Patent ductus arteriosus 		0.070 Biomarker disease BEFREE Thus, impeding MUC1 regulation of PDGFA signaling may be therapeutically beneficial for patients with PDA. 22266848 2012