MUC1, mucin 1, cell surface associated, 4582

N. diseases: 552; N. variants: 18
Disease: Multiple Myeloma ×
Source: BEFREE ×
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0026764
Disease: Multiple Myeloma
Multiple Myeloma 		0.400 Biomarker disease BEFREE We investigated induction of antigen-specific, cytotoxic T-lymphocytes to the well-defined tumor associated antigens (TAAs) hTERT, MUC1, MAGE-C1 and CS1, which have been shown to be expressed in a high proportion of cases of multiple myeloma. 31428094 2019
CUI: C0026764
Disease: Multiple Myeloma
Multiple Myeloma 		0.400 AlteredExpression disease BEFREE Moreover, MUC1 is expressed by some haematopoietic cancers, including acute myeloid leukaemia and myeloma. 29784646 2018
CUI: C0026764
Disease: Multiple Myeloma
Multiple Myeloma 		0.400 AlteredExpression disease BEFREE EMM1 cells expressed high levels of MUC1 compared with other myeloma cell lines. 30420285 2018
CUI: C0026764
Disease: Multiple Myeloma
Multiple Myeloma 		0.400 AlteredExpression disease BEFREE These findings, and the demonstration that expression of MUC1 and CD44 significantly correlate in microarrays from primary MM cells, provide support for combining GO-203 with LEN in the treatment of MM and in LEN-resistance. 28643330 2017
CUI: C0026764
Disease: Multiple Myeloma
Multiple Myeloma 		0.400 AlteredExpression disease BEFREE The MUC1-C oncoprotein is aberrantly expressed by MM cells, activates MYC and is also necessary for MM cell survival. 29050200 2017
CUI: C0026764
Disease: Multiple Myeloma
Multiple Myeloma 		0.400 AlteredExpression disease BEFREE These findings collectively provide convincing evidence that MUC1-C drives MYC expression in MM. 26907633 2016
CUI: C0026764
Disease: Multiple Myeloma
Multiple Myeloma 		0.400 Biomarker disease BEFREE It was recently approved by the FDA and EMA for use in combination with bortezomib and dexamethasone in patients with multiple myeloma who have received ≥2 prior regimens, including bortezomib and an immunomodulatory drug. 26362997 2015
CUI: C0026764
Disease: Multiple Myeloma
Multiple Myeloma 		0.400 Biomarker disease BEFREE Polyclonal and monoclonal antibodies generated against MUC1 SP domain specifically bind a large variety of MUC1-positive human solid and haematological tumor cell lines; MUC1-positive bone marrow derived plasma cells obtained from multiple myeloma (MM)-patients, but not MUC1 negative tumors cells, and normal naive primary blood and epithelial cells. 24416403 2014
CUI: C0026764
Disease: Multiple Myeloma
Multiple Myeloma 		0.400 AlteredExpression disease BEFREE However, the functional significance of MUC1-C expression in multiple myeloma is not known. 22117045 2012
CUI: C0026764
Disease: Multiple Myeloma
Multiple Myeloma 		0.400 Biomarker disease BEFREE Moreover, the functional role of MUC1 in multiple myeloma is not known. 18575761 2008
CUI: C0026764
Disease: Multiple Myeloma
Multiple Myeloma 		0.400 AlteredExpression disease BEFREE MUC-1 mucin is an epithelial cell antigen whose aberrant expression plays a role in autoimmunity and tumor immunity in the majority of human carcinomas and multiple myeloma. 18158739 2007
CUI: C0026764
Disease: Multiple Myeloma
Multiple Myeloma 		0.400 Biomarker disease BEFREE Additionally, DMC209 specifically binds the MUC1 alpha/beta junction on full-length MUC1/TM expressed by breast and ovarian cancer cell lines and on freshly obtained, unmanipulated MUC1-positive malignant plasma cells of multiple myeloma. 17145869 2006
CUI: C0026764
Disease: Multiple Myeloma
Multiple Myeloma 		0.400 Biomarker disease BEFREE Recently, MUC1 has been detected in a variety of hematopoietic cell malignancies including T and B cell lymphomas and myelomas; however, its function in these cells is not clearly defined. 15513966 2005
CUI: C0026764
Disease: Multiple Myeloma
Multiple Myeloma 		0.400 Biomarker disease BEFREE TNFalpha in both a dose and time dependent fashion induced expression of CD11a (LFA-1), CD54 (intercellular adhesion molecule-1, ICAM-1), CD106 (vascular cell adhesion molecule-1, VCAM-1), CD49d (very late activating antigen-4, VLA-4), and/or MUC-1 on MM cell lines; as well as CD106 (VCAM-1) and CD54 (ICAM-1) expression on BMSCs. 11494147 2001
CUI: C0026764
Disease: Multiple Myeloma
Multiple Myeloma 		0.400 AlteredExpression disease BEFREE MUC1 mRNA and EGP40 mRNA and protein were detected in BM samples and PB samples from healthy donors and from patients with multiple myeloma (MM), non-Hodgkin's lymphoma (NHL) and chronic myelogenous leukaemia (CML). 11205703 2001
CUI: C0026764
Disease: Multiple Myeloma
Multiple Myeloma 		0.400 AlteredExpression disease BEFREE We first demonstrated that MM cell lines and MM patient cells express both adenovirus receptors as well as the DF3/MUC1 protein, thus providing a rationale for using adenoviruses to selectively deliver genes under the control of the DF3 promoter. 9845525 1998
CUI: C0026764
Disease: Multiple Myeloma
Multiple Myeloma 		0.400 Biomarker disease BEFREE Both CTL lines lysed MUC1+ myeloma and breast carcinoma cell lines. 9184925 1997