Stomach Carcinoma
|
0.200 |
Biomarker
|
disease |
BEFREE |
The surface marker expression suggested a tumor origin of the cells, and indicated the intestinal phenotype of a GC (CD10<sup>+</sup>, MUC1).
|
29552124 |
2018 |
Stomach Carcinoma
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Our study confirms the protective effect of MUC1 rs4072037 polymorphism on the risk of GC under the dominant model.
|
28489708 |
2018 |
Stomach Carcinoma
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
However, subtype-specific associations were observed for gastric cardia adenocarcinomas at MUC1/TRIM46/1q22 rs2070803 [HRAA versus GA+GG = 2.16; 95% confidence interval (CI) = 1.24-3.78; P = 0.0068] and LTA/TNF/6p21.33 rs1799724 (HRTT+CT versus CC = 1.30; 95% CI = 1.07-1.57; P = 0.0077), and for diffuse-type GC at PSCA/8q24.3 rs2294008 (HRTT versus CT+CC = 1.99; 95% CI = 1.33-2.97; P = 7.8E-04).
|
29028942 |
2017 |
Stomach Carcinoma
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, this meta-analysis suggested that rs4245739 polymorphism in the MUC1 gene may play a pivotal role in the pathogenesis of GC, especially for white populations.
|
28561882 |
2017 |
Stomach Carcinoma
|
0.200 |
GeneticVariation
|
disease |
GWASCAT |
Identification of new susceptibility loci for gastric non-cardia adenocarcinoma: pooled results from two Chinese genome-wide association studies.
|
26701879 |
2017 |
Stomach Carcinoma
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
We also confirmed a previously reported association for rs4072037 in MUC1 with p=6.59×10(-8) for total gastric cancer and similar estimates for cardia and non-cardia cancers.
|
26129866 |
2016 |
Stomach Carcinoma
|
0.200 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide association study of gastric adenocarcinoma in Asia: a comparison of associations between cardia and non-cardia tumours.
|
26129866 |
2016 |
Stomach Carcinoma
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Those subjects with both the risk alleles MUC1 rs9841504 and ZBTB20 rs4072037 had a greater than 3-fold increased risk of gastric cancer.
|
27127881 |
2016 |
Stomach Carcinoma
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
In summary, these results suggest that the MUC1 rs4072037G allele may be a low-penetrating protection factor for GCa risk in Chinese populations.
|
26910281 |
2016 |
Stomach Carcinoma
|
0.200 |
GeneticVariation
|
disease |
GWASCAT |
Loss-of-function variants in ATM confer risk of gastric cancer.
|
26098866 |
2015 |
Stomach Carcinoma
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Our results confirm an association between gastric cancer in Europeans and three loci previously reported in Asians, MUC1, PRKAA1 and PSCA, refine the association signal at PRKAA1 and support a pathogenic role for the tandem repeat identified in MUC1.
|
26098866 |
2015 |
Stomach Carcinoma
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Associations of genetic variants in the PSCA, MUC1 and PLCE1 genes with stomach cancer susceptibility in a Chinese population.
|
25658482 |
2015 |
Stomach Carcinoma
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
The aim of this study was to determine whether rs4072037A > G in MUC1 at 1q22 and rs2274223A > G in PLCE1 at 10q23 are associated with a risk of gastric cancer in a Korean population.
|
24254309 |
2014 |
Stomach Carcinoma
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Polymorphisms of PSCA (rs2976392, rs2294008) and MUC1 (rs4072037) genes are associated with GC and HRAG.
|
25503145 |
2014 |
Stomach Carcinoma
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Recently, genome-wide association studies (GWAS) on Japanese and Chinese populations identified chromosome 1q22 as a GC susceptibility locus which harbors mucin 1 gene (MUC1) encoding a cell membrane-bound mucin protein.
|
24810688 |
2014 |
Stomach Carcinoma
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, MUC1 rs4072037 polymorphism may be used as potential biomarker for cancer susceptibility particularly for gastric cancer and for Asian population.
|
24755768 |
2014 |
Stomach Carcinoma
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Association studies involving MUC1 rs4072037 polymorphism and GC risk were identified up to June 30, 2012.
|
24072653 |
2013 |
Stomach Carcinoma
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Overall, our data indicated that common genetic variations in MUC1 gene might not make a major contribution to the risk of H. pylori infection and non-cardia gastric cancer in our studied population.
|
24460302 |
2013 |
Stomach Carcinoma
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
In this two-stage study, we selected 24 putative functional tag single-nucleotide polymorphisms (tagSNPs) for six H.pylori-related host genes, MUC1, toll-like receptor 4 (TLR4), protein tyrosine phosphatase, non-receptor type 11 (PTPN11), IL-1B, PGC and PGA3-5, and analyzed their influence and interaction with H.pylori on the GA and GC risks.
|
23455381 |
2013 |
Stomach Carcinoma
|
0.200 |
Biomarker
|
disease |
BEFREE |
From the second candidate locus identified using the GWAS, 1q22, we found the Mucin 1 (MUC1) gene encoding a cell membrane-bound mucin protein as another gene related to diffuse-type GC.
|
23057512 |
2013 |
Stomach Carcinoma
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Our study suggested rs2294008 in the PSCA gene to be associated with increased risk of gastric cancer and rs2070803 in MUC1 to play a protective role in a Chinese population.
|
22938426 |
2012 |
Stomach Carcinoma
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
The rs4072037 polymorphism in MUC1 was associated with a reduced risk of GC of intestinal histological type (OR 0.4; 95% CI 0.2-0.9) and a reduced risk of oesophageal squamous cell cancer (OR 0.5; 95% CI 0.2-1.0), but not oesphageal adenocarcinoma.
|
22805490 |
2012 |
Stomach Carcinoma
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
The SNPs rs2070803 and rs4072037 in MUC1 might be used to identify individuals at risk for this type of gastric cancer.
|
21070779 |
2011 |
Stomach Carcinoma
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Overall, our data provide evidence that some common variations in MUC1 and MUC5AC genes contribute to an elevated risk of stomach cancer.
|
19924550 |
2010 |
Stomach Carcinoma
|
0.200 |
GeneticVariation
|
disease |
GWASCAT |
A shared susceptibility locus in PLCE1 at 10q23 for gastric adenocarcinoma and esophageal squamous cell carcinoma.
|
20729852 |
2010 |