|
Malignant tumor of colon
|
0.300 |
Biomarker
|
disease |
BEFREE |
Jun N-terminal kinase 1 (JNK1) pathway and Mucin 2 (MUC2) were the potential downstream proteins of miR-613/ATOH1. miR-613 is an oncogene in CC and promotes the proliferation, invasion and migration of CC cells by targeting ATOH1 likely via activating JNK1 pathway and upregulating MUC2.
|
30219232 |
2018 |
|
Malignant tumor of colon
|
0.300 |
Biomarker
|
disease |
BEFREE |
Most importantly, MUC2 is a potential prognostic indicator for colon cancer.
|
28725043 |
2017 |
|
Malignant tumor of colon
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
No goblet cells were to be found in colon cancer and levels of Hath1 mRNA and Hath1, Muc2 mRNA and Muc2 were significantly down-regulated.
|
23464457 |
2012 |
|
Malignant tumor of colon
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Bile acid regulates MUC2 transcription in colon cancer cells via positive EGFR/PKC/Ras/ERK/CREB, PI3K/Akt/IkappaB/NF-kappaB and p38/MSK1/CREB pathways and negative JNK/c-Jun/AP-1 pathway.
|
20198339 |
2010 |
|
Malignant tumor of colon
|
0.300 |
Biomarker
|
disease |
RGD |
Gene expression profile and genomic alterations in colonic tumours induced by 1,2-dimethylhydrazine (DMH) in rats.
|
20459814 |
2010 |
|
Malignant tumor of colon
|
0.300 |
Biomarker
|
disease |
BEFREE |
In the present study, we have evaluated the detection of colon cancer lymph node metastases by real-time RT-PCR quantitation of the epithelial-specific cytokeratin 20 (CK20) and mucin 2 (MUC2) mRNAs.
|
19119477 |
2009 |
|
Malignant tumor of colon
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Macrophage-derived interleukin-6 up-regulates MUC1, but down-regulates MUC2 expression in the human colon cancer HT-29 cell line.
|
19201396 |
2009 |
|
Malignant tumor of colon
|
0.300 |
Biomarker
|
disease |
RGD |
K-ras mutations and mucin profile in preneoplastic lesions and colon tumors induced in rats by 1,2-dimethylhydrazine.
|
17847023 |
2008 |
|
Malignant tumor of colon
|
0.300 |
Biomarker
|
disease |
BEFREE |
This may have important implications for understanding the role of galectin-3 and MUC2 in colon cancer metastasis.
|
16285957 |
2005 |
|
Malignant tumor of colon
|
0.300 |
Biomarker
|
disease |
BEFREE |
Human colon cancers differ in amounts of MUC2 mucin synthesized.
|
14678781 |
2004 |
|
Malignant tumor of colon
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Phorbol 12-myristate 13-acetate (PMA) treatment of colon cancer cell lines increases MUC2 expression, so we have undertaken a detailed analysis of the effects of PMA on the promoter activity of the 5'-flanking region of the MUC2 gene using stably and transiently transfected promoter reporter vectors.
|
12077118 |
2002 |
|
Malignant tumor of colon
|
0.300 |
Biomarker
|
disease |
BEFREE |
MUC2 RT-PCR was negative in six nodes from three patients with non-malignant colon disease and positive in histologically positive lymph nodes from six of six (100%) stage III colon cancers.
|
10757125 |
2000 |
|
Malignant tumor of colon
|
0.300 |
Biomarker
|
disease |
BEFREE |
This study provides direct evidence that MUC2 plays an important role in colon cancer metastasis.
|
9922317 |
1999 |
|
Malignant tumor of colon
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Localization of mucin (MUC2 and MUC3) messenger RNA and peptide expression in human normal intestine and colon cancer.
|
8020672 |
1994 |
|
Malignant tumor of colon
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
MUC2 or MUC3 mRNA levels were increased in colloid colon cancer compared with normal colon, however in well- and moderately well-differentiated colon cancers MUC1, 2 and 3 mRNA levels were decreased.
|
7678777 |
1993 |
|
Malignant tumor of colon
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
In contrast, the colon cancer cell lines tested in culture express apomucin and mRNA coded by MUC2 but not by MUC1.
|
2064602 |
1991 |