Adenocarcinoma
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Conversely, MUC4 and MUC5AC were similarly expressed in the sinonasal adenocarcinoma subtypes tested.
|
31076280 |
2019 |
Adenocarcinoma
|
0.100 |
AlteredExpression
|
group |
BEFREE |
We have previously studied the generation of immune responses after vaccination with tumor-associated carbohydrate antigen (TACA)-containing glycopeptides from the tandem repeat (TR) sequence of MUC4, an aberrantly expressed mucin in pancreatic adenocarcinomas.
|
30952968 |
2019 |
Adenocarcinoma
|
0.100 |
Biomarker
|
group |
BEFREE |
MUC4 immunohistochemistry is useful in distinguishing epithelioid mesothelioma from adenocarcinoma and squamous cell carcinoma of the lung.
|
29317712 |
2018 |
Adenocarcinoma
|
0.100 |
AlteredExpression
|
group |
BEFREE |
We showed that MUC4 expression is associated with a poorer overall survival in TCGA cancers with different localizations including pancreatic cancer, bladder cancer, colon cancer, lung adenocarcinoma, lung squamous adenocarcinoma, skin cancer and stomach cancer.
|
30236127 |
2018 |
Adenocarcinoma
|
0.100 |
Biomarker
|
group |
BEFREE |
In this study, the immunohistochemical expression of MUC1 and Mucin-4 (MUC4) was analyzed in a series of 106 surgically operated stage I-IV pulmonary adenocarcinomas.
|
27481516 |
2016 |
Adenocarcinoma
|
0.100 |
AlteredExpression
|
group |
BEFREE |
We evaluated by immunohistochemistry the expression of MUC4, MUC16 (CA-125) and galectin-3 in 31 pancreatic adenocarcinomas.
|
26613889 |
2016 |
Adenocarcinoma
|
0.100 |
Biomarker
|
group |
BEFREE |
Aberrant methylation of MUC1 and MUC4 promoters are potential prognostic biomarkers for pancreatic ductal adenocarcinomas.
|
27283771 |
2016 |
Adenocarcinoma
|
0.100 |
Biomarker
|
group |
BEFREE |
Using antisense-MUC4-RNA transfected adenocarcinoma cells, we discovered that the loss of MUC4 expression results in epithelial-mesenchymal transition (EMT).
|
24037917 |
2014 |
Adenocarcinoma
|
0.100 |
AlteredExpression
|
group |
BEFREE |
It has been shown that MUC4 pattern of expression is modified during esophageal carcinogenesis, with a progressive increase from metaplastic lesions to adenocarcinoma.
|
21889495 |
2011 |
Adenocarcinoma
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The results have revealed that MUC4 mucin is overexpressed in CD133(+) and CD133(-) pancreatic cells (PCs) detected in patient's adenocarcinoma tissues while no significant expression was seen in normal pancreatic tissues.
|
20303649 |
2010 |
Adenocarcinoma
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The gastric mucosal levels of the pro-inflammatory cytokine Interleukin 6 (IL-6) have been reported to be increased in Helicobacter pylori-infected subjects and, in gastric adenocarcinomas, the up-regulation of intestinal mucin genes (MUC2 and MUC4) has been detected.
|
18573283 |
2008 |
Adenocarcinoma
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Here, we report the expression profile of MUC4 in gastric adenocarcinomas and its function in poorly differentiated gastric non-signet ring cell carcinoma (non-SRCC) type cells.
|
18781152 |
2008 |
Adenocarcinoma
|
0.100 |
AlteredExpression
|
group |
BEFREE |
MUC4, a transmembrane mucin, is aberrantly expressed in pancreatic adenocarcinomas while remaining undetectable in the normal pancreas.
|
17406026 |
2007 |
Adenocarcinoma
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The transmembrane mucin, MUC4, is aberrantly expressed with a high incidence in human pancreatic adenocarcinomas and plays an important role in the pathogenesis of the disease.
|
16007204 |
2005 |
Adenocarcinoma
|
0.100 |
Biomarker
|
group |
BEFREE |
Therefore MUC4 appears as a useful biological marker for the diagnosis of ductal adenocarcinomas.
|
15461591 |
2005 |
Adenocarcinoma
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Altogether, these results indicate that upregulation of MUC4 by TGF-beta is restricted to well-differentiated pancreatic cancer cells, and point out a novel mechanism for TGF-beta as a key molecule in targeting MUC4 overexpression in pancreatic adenocarcinomas.
|
15184872 |
2004 |
Adenocarcinoma
|
0.100 |
Biomarker
|
group |
BEFREE |
Aberrant expression of membrane mucins MUC3 and MUC4 and of a mucin-associated carbohydrate tumor antigen Sialyl Le(x) in PanINs and adenocarcinoma further supports the progression model for pancreatic adenocarcinoma.
|
12657964 |
2003 |
Adenocarcinoma
|
0.100 |
AlteredExpression
|
group |
BEFREE |
In contrast, MUC4 was strongly expressed in gallbladder adenocarcinomas.
|
11101635 |
2000 |
Adenocarcinoma
|
0.100 |
AlteredExpression
|
group |
BEFREE |
As expected, the highest reactivity for MUC1 and MUC4 expression was observed mainly in the adenocarcinoma histotype which is mucin secreting.
|
8694545 |
1996 |