MUC4, mucin 4, cell surface associated, 4585

N. diseases: 155; N. variants: 17
Disease: Secondary Neoplasm ×
Source: BEFREE ×
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C2939419
Disease: Secondary Neoplasm
Secondary Neoplasm 		0.050 Biomarker group BEFREE The detection of clinical samples indicates that MUC4/Y is significantly positive-correlated with tumor invasion and distant metastases. 25367394 2014
CUI: C2939419
Disease: Secondary Neoplasm
Secondary Neoplasm 		0.050 Biomarker group BEFREE The mucin MUC4 is a high molecular weight membrane-bound transmembrane glycoprotein that is frequently detected in invasive and metastatic cancer. 24037917 2014
CUI: C2939419
Disease: Secondary Neoplasm
Secondary Neoplasm 		0.050 Biomarker group BEFREE Due to the size, glycosylation, and location in the plasma membrane of the sialomucin complex Muc4, which has been implicated in ErbB2 signaling, in the repression of apoptosis and cell adhesion, and in tumor metastasis, studies were initiated to determine whether its presence could influence cell sensitivity to anticancer drugs. 12732353 2003
CUI: C2939419
Disease: Secondary Neoplasm
Secondary Neoplasm 		0.050 AlteredExpression group BEFREE In the current studies, we investigated the role of MUC4/SMC in tumor metastasis by regulating SMC expression of tumor transplants in vivo. 10918186 2000
CUI: C2939419
Disease: Secondary Neoplasm
Secondary Neoplasm 		0.050 Biomarker group BEFREE The study suggests that overexpression of novel tracheobronchial mucin genes may result in an increased likelihood of post-operative lung-cancer recurrence or metastases. 8980247 1996