MMUT, methylmalonyl-CoA mutase, 4594

N. diseases: 147; N. variants: 177
Disease: Malignant Neoplasms ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms 		0.100 AlteredExpression group BEFREE MCM protein expression was found to be up-regulated in LSIL, HSIL and in malignancies to a greater extent 29373905 2018
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms 		0.100 Biomarker group BEFREE MCM proteins are involved in DNA repair and expected to be participating in the early stage of cancer. 29719595 2018
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms 		0.100 PosttranslationalModification group BEFREE In this review, we summarize the currently available data regarding the regulatory mechanisms and functional consequences of MCM phosphorylation and seek the probability that protein kinase inhibitor can be used therapeutically to target MCM phosphorylation in cancer. 30062004 2018
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms 		0.100 Biomarker group BEFREE Silica-Calix Hybrid Composite of Allyl Calix[4]arene Covalently Linked to MCM-41 Nanoparticles for Sustained Release of Doxorubicin into Cancer Cells. 30023773 2018
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms 		0.100 AlteredExpression group BEFREE MCM8, one of the MCM proteins playing a critical role in DNA repairing and recombination, was found to have overexpression and increased DNA copy number in a variety of human malignancies. 28481876 2017
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms 		0.100 Biomarker group BEFREE Due to the importance of MCM complex, MCM7 gene has been regarded as a candidate gene for cancer development. 27837251 2017
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms 		0.100 Biomarker group BEFREE MCM protein deficiency results in genome instability and high rates of cancer in mouse models. 25762552 2015
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms 		0.100 GeneticVariation group BEFREE Nonetheless, partial depletion of Mcm proteins leads to cancers and stem cell deficiencies. 22158038 2012
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms 		0.100 GeneticVariation group BEFREE MUT-TP53 2.0: a novel versatile matrix for statistical analysis of TP53 mutations in human cancer. 20572016 2010
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms 		0.100 Biomarker group BEFREE MCM proteins emerge as exceptionally promising markers for cancer screening and early diagnosis. 16147513 2005