Adenoma of large intestine
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
However, limited data are available on the duodenal phenotype of patients with multiple colorectal adenomas (10-99) without a germline APC or MUTYH mutation.
|
29215473 |
2018 |
Adenoma of large intestine
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In order to clarify an association between MUTYH heterozygotes and adenomas, we evaluated the frequency and types of MUTYH mutations and variants in 72 North-African Jews having few (≥3) colorectal adenomas with or without early onset (<50 years) CRC compared to 29 healthy controls.
|
25822476 |
2015 |
Adenoma of large intestine
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The second cohort contained 921 patients with colorectal cancer <50 years and <10 reported colorectal adenomas who had undergone MUTYH mutation testing.
|
24620956 |
2015 |
Adenoma of large intestine
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Three SNPS modified the effect of smoking (MUTYH interaction p = 0.002; OGG1 interaction p = 0.013); FEN1 interaction p = 0.013)), one SNP in LIG3 modified the effect of alcohol consumption (interaction p = 0.024) and two SNPs in LIG3 modified the effect of dietary folate (interaction p = 0.001 and p = 0.08) on colorectal adenoma risk.
|
23951112 |
2013 |
Adenoma of large intestine
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Our data suggest that the contribution of bi-allelic MUTYH mutations to the development of CRC in Dutch non-polyposis patients that meet clinical genetic referral criteria, and to the development of low number of colorectal adenomas in non-CRC patients, is likely to be low.
|
23007840 |
2013 |
Adenoma of large intestine
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Biallelic inherited mutations in the oxidative DNA damage repair gene MUTYH predispose to colorectal adenomas and colorectal carcinoma (CRC) with high penetrance.
|
23852950 |
2013 |
Adenoma of large intestine
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Biallelic germline mutations in the base excision repair enzyme gene MUTYH lead to multiple colorectal adenomas and carcinomas referred to as MUTYH-associated polyposis.
|
22926731 |
2012 |
Adenoma of large intestine
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Germline mutations in the base excision repair gene MUTYH have been associated with recessive inheritance of multiple colorectal adenomas.
|
22744763 |
2012 |
Adenoma of large intestine
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
To determine the prevalence of pathogenic APC and MUTYH mutations in patients with multiple colorectal adenomas who had undergone genetic testing and to compare the prevalence and clinical characteristics of APC and MUTYH mutation carriers.
|
22851115 |
2012 |
Adenoma of large intestine
|
0.100 |
Biomarker
|
disease |
BEFREE |
The MUTYH gene encodes a DNA glycosylase that can initiate the excision repair of adenine mispaired with 8-hydroxyguanine (8OHG) and is responsible for a susceptibility to multiple colorectal adenomas and carcinomas.
|
21826668 |
2011 |
Adenoma of large intestine
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Recessively inherited mutations in the base excision repair gene MYH have recently been associated with predisposition to colorectal adenomas and cancer.
|
20939750 |
2011 |
Adenoma of large intestine
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Biallelic inactivating germline mutations in the base excision repair MUTYH (MYH) gene have been shown to predispose to MUTYH-associated polyposis (MAP), which is characterized by multiple colorectal adenomas and carcinomas.
|
20848659 |
2010 |
Adenoma of large intestine
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
MYH-associated polyposis is an inherited autosomal recessive disease, linked to biallelic germline MYH mutations, which predisposes to the development of multiple colorectal adenomas and cancer.
|
19404084 |
2009 |
Adenoma of large intestine
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Testing for mutations in the MUTYH gene is indicated in patients who have multiple colorectal adenomas or a family history suggestive of autosomal recessive colorectal cancer and for the siblings and spouses of patients with MAP in order to inform surveillance and treatment for patients and their families.
|
19414147 |
2009 |
Adenoma of large intestine
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The expression of MUTYH protein in colorectal adenomas or cancer was studied by IHC using three different (1 polyclonal and 2 monoclonal) antibodies in six samples from patients with biallelic MUTYH mutations, in three samples from patients with a single MUTYH mutation, and in 11 samples from patients without MUTYH mutations.
|
19031083 |
2009 |
Adenoma of large intestine
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Recently, biallelic mutations in MUTYH have also been identified in patients with multiple colorectal adenomas and in APC-negative patients with FAP.
|
19531215 |
2009 |
Adenoma of large intestine
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Biallelic germline mutations of MUTYH have been shown to predict familial and sporadic multiple colorectal adenomas and carcinomas, however, whether there is an association between single nucleotide polymorphisms (SNPs) of MUTYH and sporadic colorectal cancer (CRC) risk has remained unclear.
|
18271935 |
2008 |
Adenoma of large intestine
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Germ-line biallelic mutations in the MYH gene are associated with the development of multiple colorectal adenomas and colorectal carcinoma (CRC).
|
18564191 |
2008 |
Adenoma of large intestine
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Conclusively, two novel mutations of MYH and a novel OGG1 polymorphism seemed to be associated with multiple colorectal adenomas in Korean families, differing from those in other ethnic groups.
|
17252231 |
2007 |
Adenoma of large intestine
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Inherited MYH mutations predispose to colorectal adenomas and cancer.
|
17219200 |
2007 |
Adenoma of large intestine
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We conclude that MUTYH suppresses spontaneous tumorigenesis in mammals, thus providing experimental evidence for the association between biallelic germ-line MUTYH mutations and a recessive form of human hereditary colorectal adenoma and carcinoma.
|
17638869 |
2007 |
Adenoma of large intestine
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
A large proportion of non-FAP non-HNPCC patients with multiple colorectal adenomas have been reported to carry germline mutations on the MYH gene.
|
17949294 |
2007 |
Adenoma of large intestine
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Recently, it has been shown that germline mutations in MUTYH predispose to MUTYH-associated polyposis (MAP), an autosomal recessive disorder characterised by multiple colorectal adenomas and carcinomas.
|
17161978 |
2007 |
Adenoma of large intestine
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Germline mutations of the MYH gene in Korean patients with multiple colorectal adenomas.
|
17703316 |
2007 |
Adenoma of large intestine
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The expression of MYH, MSH2, MLH1, and MSH6 proteins was studied by immunohistochemistry in 20 samples (colorectal adenomas or cancer) from 18 patients with biallelic MYH mutation, in 11 samples from patients with germline adenomatous polyposis coli (APC) mutations, in 20 samples from patients with sporadic colorectal cancers, and in 10 samples from patients with normal colonic mucosa without malignancies.
|
16890597 |
2006 |