MYBL1, MYB proto-oncogene like 1, 4603

N. diseases: 25; N. variants: 1
Disease: Agenesis of corpus callosum ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0175754
Disease: Agenesis of corpus callosum
Agenesis of corpus callosum 		0.090 AlteredExpression disease BEFREE Although the predominant phenotype of the MYB-NFIB GEMM was B-cell leukemia, we also generated a MYB-activated ACC-like mammary tumor cell line. 31606723 2019
CUI: C0175754
Disease: Agenesis of corpus callosum
Agenesis of corpus callosum 		0.090 GeneticVariation disease BEFREE It is concluded that MYBL1 alterations are detected in primary cutaneous ACC but are apparently less common compared with MYB and NFIB alterations. 29570128 2018
CUI: C0175754
Disease: Agenesis of corpus callosum
Agenesis of corpus callosum 		0.090 GeneticVariation disease BEFREE We also analyzed ACC-specific MYB and MYBL1 gene rearrangements by fluorescence in situ hybridization (FISH). 29496310 2018
CUI: C0175754
Disease: Agenesis of corpus callosum
Agenesis of corpus callosum 		0.090 GeneticVariation disease BEFREE The t(6;9) (q22-23;p23-24) translocation, resulting in a MYB-NFIB gene fusion has been found in ACCs from the salivary glands and other organs. 27859477 2017
CUI: C0175754
Disease: Agenesis of corpus callosum
Agenesis of corpus callosum 		0.090 AlteredExpression disease BEFREE Reciprocal MYB and MYBL1 expression was consistently found in ACCs. 26631609 2016
CUI: C0175754
Disease: Agenesis of corpus callosum
Agenesis of corpus callosum 		0.090 AlteredExpression disease BEFREE Interestingly, tumors with MYB and MYBL1 translocations displayed similar gene expression profiles, and the combined MYB and MYBL1 expression correlated with outcome, suggesting that the related MYB proteins are interchangeable oncogenic drivers in ACC. 26631070 2016
CUI: C0175754
Disease: Agenesis of corpus callosum
Agenesis of corpus callosum 		0.090 AlteredExpression disease BEFREE The majority of ACCs express the oncogenic transcription factor MYB (also c-myb), often in the context of a MYB gene rearrangement. 27566443 2016
CUI: C0175754
Disease: Agenesis of corpus callosum
Agenesis of corpus callosum 		0.090 GeneticVariation disease BEFREE A significant portion of adenoid cystic carcinoma (ACC) cases are characterized by a t(6;9)(q22-23;p23-24) translocation that originates a MYB-NFIB fusion oncogene. 26309189 2015
CUI: C0175754
Disease: Agenesis of corpus callosum
Agenesis of corpus callosum 		0.090 GeneticVariation disease BEFREE Many ACCs have a t(6;9) chromosomal translocation resulting in a MYB-NFIB fusion gene, but the clinical significance is unclear. 25963073 2015