MYBPC3, myosin binding protein C3, 4607

N. diseases: 100; N. variants: 418
Disease: Atrial Fibrillation ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0004238
Disease: Atrial Fibrillation
Atrial Fibrillation 		0.030 GeneticVariation disease BEFREE One thousand forty adult HCM patients, without baseline AF and with likely pathogenic or pathogenic variation in either MYH7 (n=296), MYBPC3 (n=659), or thin filament genes (n=85), were included. 30354366 2018
CUI: C0004238
Disease: Atrial Fibrillation
Atrial Fibrillation 		0.030 GeneticVariation disease BEFREE AF occurred in 74 patients with HC (31%), with no difference among groups (31% in MYBPC3, 37% in MYH7 and 18% in other genotypes, p = 0.15), paroxysmal/persistent AF (12%, 18%, and 12%, respectively; p = 0.53), paroxysmal/persistent evolved to permanent (12%, 12%, and 3%, p = 0.36) or permanent AF (7%, 7%, and 3%, p = 0.82). 26869393 2016
CUI: C0004238
Disease: Atrial Fibrillation
Atrial Fibrillation 		0.030 GeneticVariation disease BEFREE Patients with MYH7 gene mutations had a larger left atrium and higher frequency of atrial fibrillation than did patients with MYBPC3 gene mutations. 24093860 2013