Adenocarcinoma
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Therefore, in a series of gastric adenocarcinomas we studied the association of p27(KIP1) expression with H. pylori genotype (vacA, cagA, cagE and virB11) and the involvement of C-MYC in this process.
|
20059402 |
2010 |
Adenocarcinoma
|
0.400 |
Biomarker
|
group |
BEFREE |
We demonstrate that IBD-associated intestinal adenocarcinomas have a high frequency of c-MYC amplification that is associated with mucinous and signet ring cell differentiation.
|
29788391 |
2018 |
Adenocarcinoma
|
0.400 |
AlteredExpression
|
group |
BEFREE |
K-RAS point mutation, as well as amplification of C-MYC and C-ERBB2 were searched in 84 primary colon adenocarcinomas resected with curative intent.
|
15493579 |
2004 |
Adenocarcinoma
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Transgenic MYC expression drives invasive adenocarcinomas in the murine prostate.
|
22585994 |
2012 |
Adenocarcinoma
|
0.400 |
GeneticVariation
|
group |
BEFREE |
C-MYC locus amplification as metastasis predictor in intestinal-type gastric adenocarcinomas: CGH study in Brazil.
|
16886612 |
2006 |
Adenocarcinoma
|
0.400 |
Biomarker
|
group |
BEFREE |
c-MYC gain (but not chromosome 8 gain or c-MYC amplification) was an independent poor-prognostic factor for DFS and OS in lung adenocarcinomas, both in full cohort and stage I cancer, and possibly for DFS in EGFR-mutant adenocarcinomas.
|
24809777 |
2014 |
Adenocarcinoma
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Considering that α1 subunit/<i>ITGA1</i> expression is correlated with MYC in more than 70% of colon adenocarcinomas, we postulated that the integrin α1β1 has a pro-tumoral contribution to CRC.
|
28933766 |
2017 |
Adenocarcinoma
|
0.400 |
Biomarker
|
group |
BEFREE |
These genes include 1) those important to androgen metabolism in the prostate, the androgen receptor and steroid 5 alpha reductase genes; 2) those that map to the 10q (PLAU) and 7q (MET) chromosomal regions found deleted in some prostate carcinomas, and 3) proto-oncogenes (ERBB2, INT2, and MYC) and tumor suppressor gene loci (RB1, TP53 and D17S5) found altered in adenocarcinomas of the breast, colon and lung.
|
1552612 |
1992 |
Adenocarcinoma
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Dual-color fluorescence in situ hybridization (FISH) for the C-MYC gene and chromosome 8 centromere was performed in 11 gastric adenocarcinomas.
|
16309200 |
2006 |
Adenocarcinoma
|
0.400 |
Biomarker
|
group |
BEFREE |
Increased copy number of the ERBB2 (1 of 22), GATA4 (1 of 22), KRAS (2 of 22), C-MYC (1 of 22), CCNE1 (2 of 22), and CCND1 (2 of 22) genes was also observed in one or more Barrett's adenocarcinomas with HGD.
|
14581353 |
2003 |
Adenocarcinoma
|
0.400 |
GeneticVariation
|
group |
BEFREE |
The aim of the present study is to determine the presence and molecular integrity of high-risk HPV types in colorectal adenocarcinomas and to assess whether viral DNA is related to common proto-oncogene alterations, such as k-ras mutations and c-myc gene amplification, in colorectal cancer.
|
20232185 |
2010 |
Adenocarcinoma
|
0.400 |
Biomarker
|
group |
BEFREE |
In the present study, amplification of the proto-oncogene c-myc was determined by means of differential polymerase chain reaction analysis of metaplastic specialized epithelium, low-grade dysplasia, high-grade dysplasia, and invasive adenocarcinoma obtained by microscopic dissection of 43 esophagectomy specimens.
|
11392879 |
2001 |
Adenocarcinoma
|
0.400 |
AlteredExpression
|
group |
BEFREE |
We show that deregulated c-MYC expression in this inducible system results in the formation of invasive mammary adenocarcinomas, many of which fully regress following c-MYC deinduction.
|
11175856 |
2001 |
Adenocarcinoma
|
0.400 |
Biomarker
|
group |
BEFREE |
The c-myc gene was amplified 5-7-fold in two adenocarcinomas, the H-ras gene 3 5-fold in one adenocarcinoma, while the K-ras and the neu gene were amplified in lung metastases from a colorectal and a breast cancer primary respectively.
|
2547415 |
1989 |
Adenocarcinoma
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Interference of mouse polyomavirus with the c-myc gene and its product in mouse mammary adenocarcinomas.
|
12851682 |
2003 |
Adenocarcinoma
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Firstly, lentivirus-mediated transduction of KRAS(G12V), MYC and human papillomavirus 16 (HPV16) E6/E7 under the control of a tetracyclin-inducible promoter efficiently immortalized and transformed primary HPDECs, which gave rise to adenocarcinomas subcutaneously in an immune-deficient mouse xenograft model, depending on expression of the four genes.
|
24858378 |
2014 |
Adenocarcinoma
|
0.400 |
Biomarker
|
group |
BEFREE |
Whereas the frequency of MYC amplification was similar to adenocarcinoma (10.5% versus 4%, P = .2), the frequency of PTGER4 amplification was higher than adenocarcinoma (10.5% versus 0.3%, P = .01).
|
28899736 |
2018 |
Adenocarcinoma
|
0.400 |
Biomarker
|
group |
BEFREE |
In the context of compound Pten/p53 heterozygosity, c-MYC-initiated cells progress to prostatic intraepithelial neoplasia (mPIN) and adenocarcinoma lesions with marked heterogeneity within the same prostate glands.
|
21685943 |
2012 |
Adenocarcinoma
|
0.400 |
GeneticVariation
|
group |
BEFREE |
By contrast, mice with both alterations (Hoxb13-MYC∣Hoxb13-Cre∣Pten(Fl/Fl), hereafter, BMPC mice) developed lethal adenocarcinoma with distant metastases and widespread genome CNAs that were independent of forced disruption of Tp53 and telomere shortening.
|
26554830 |
2016 |
Adenocarcinoma
|
0.400 |
AlteredExpression
|
group |
BEFREE |
To evaluate MYC copy number and its protein expression, we performed fluorescence in situ hybridization and immunohistochemical analyses in five early gastric adenocarcinomas in individuals from northern Brazil.
|
18262050 |
2008 |
Adenocarcinoma
|
0.400 |
AlteredExpression
|
group |
BEFREE |
In this study, we have employed both indirect immunofluorescence and ELISA assays to compare the relative levels of c-myc protein in cell lines derived from normal human colon and colon adenocarcinomas.
|
3283655 |
1988 |
Adenocarcinoma
|
0.400 |
Biomarker
|
group |
BEFREE |
This study was conducted to assess the frequencies of protein overexpression and gene amplification of Myc and to identify the mechanisms of Myc gene amplification, especially with regards to its possible coamplification with ERBB2 or EGFR in gastric adenocarcinomas.
|
17431415 |
2007 |
Adenocarcinoma
|
0.400 |
Biomarker
|
group |
BEFREE |
Quantitative analysis revealed that in colonic adenocarcinomas an average of 66.1% and in metastatic deposits 83.1% of the myc gene DNA was hypomethylated at this site, as compared to a value of 9.2% in normal colonic mucosa.
|
1586594 |
1992 |
Adenocarcinoma
|
0.400 |
Biomarker
|
group |
CTD_human |
PIAS3, SHP2 and SOCS3 Expression patterns in Cervical Cancers: Relevance with activation and resveratrol-caused inactivation of STAT3 signaling.
|
26432044 |
2015 |
Adenocarcinoma
|
0.400 |
AlteredExpression
|
group |
LHGDN |
Gains and amplifications of c-myc, EGFR, and 20.q13 loci in the no dysplasia-dysplasia-adenocarcinoma sequence of Barrett's esophagus.
|
18559552 |
2008 |