|
Plasmablastic lymphoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
MYC rearrangement was frequently identified in PBL patients, and IGH was the partner gene in an overwhelming majority of MYC rearrangements.
|
31348551 |
2020 |
|
Plasmablastic lymphoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, aberrant coexpression of MYC and PRDM1/Blimp1α owing to genetic changes is responsible for the phenotype of plasmablastic lymphoma cases.
|
27687004 |
2017 |
|
Plasmablastic lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Although they harbored similar pathological features, Epstein-Barr virus positive plasmablastic lymphomas showed a significant increase in MYC gene rearrangement and had a better 2-year event-free survival than Epstein-Barr virus negative cases (P=0.049).
|
27175027 |
2016 |
|
Plasmablastic lymphoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In this study, two-thirds of PBL cases assessed were associated with MYC rearrangement and all showed MYC overexpression.
|
26055271 |
2015 |
|
Plasmablastic lymphoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Plasmablastic lymphoma of the stomach with C-MYC rearrangement in an immunocompetent young adult: a case report.
|
25634193 |
2015 |
|
Plasmablastic lymphoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In human B-cell tumors, MYC rearrangements involving the 8q24 region and immunoglobulin heavy or light genes are a hallmark of Burkitt lymphoma (BL), but can also occur in other lymphoid malignancies, that include diffuse large B-cell lymphoma (DLBCL), B-cell lymphoma, unclassifiable, with features intermediate between DLBCL and Burkitt lymphoma (BCLU), plasma cell myeloma (PCM), mantle cell lymphoma (MCL) and plasmablastic lymphoma.
|
25199984 |
2014 |
|
Plasmablastic lymphoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Notably, both plasmablastic transformation cases also carried MYC gene rearrangements on chromosome 8q24, which have been frequently identified in de novo plasmablastic lymphoma.
|
23791008 |
2013 |
|
Plasmablastic lymphoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
MYC rearrangements are frequent in plasmablastic lymphomas, advanced plasma cell myelomas and a subgroup of diffuse large B-cell lymphomas, but their presence in ALK-positive large B-cell lymphomas is unknown.
|
23599149 |
2013 |
|
Plasmablastic lymphoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Immunoglobulin heavy chain/(IGH)/MYC translocation was detected in half of the PBL-E cases.
|
22958176 |
2012 |
|
Plasmablastic lymphoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Extraoral plasmablastic lymphoma with intravascular component and MYC translocation.
|
21239197 |
2012 |
|
Plasmablastic lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our results reinforce the notion that EBV infection and MYC rearrangements are important events in the pathogenesis of oral PBL.
|
21783402 |
2011 |
|
Plasmablastic lymphoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
MYC rearrangement is a recurring genetic abnormality in several aggressive B-cell lymphomas including: Burkitt lymphoma, diffuse large B-cell lymphoma; B-cell lymphoma, unclassifiable with features intermediate between diffuse large B-cell lymphoma and Burkitt lymphoma; rare de novo acute lymphoblastic lymphoma/leukemia, transformed follicular lymphoma, and plasmablastic lymphoma.
|
21490439 |
2011 |
|
Plasmablastic lymphoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
MYC rearrangements were identified in 20 of 41 (49%) PBL and the immunoglobulin (IG) genes were the partners in most tumors.
|
20962620 |
2010 |
|
Plasmablastic lymphoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
This study aimed to assess the impact of karyotypic complexity, in correlation with comprehensive immunophenotypic analyses on the diagnosis and clinical outcomes of 34 cases of MYC-IG rearranged lymphomas that included Burkitt lymphoma (twenty-two cases), diffuse large B-cell lymphoma (three cases), unclassifiable B-cell lymphoma with features intermediate between diffuse large B-cell lymphoma and Burkitt lymphoma (six cases), and plasmablastic lymphoma (three cases).
|
20348878 |
2010 |
|
Plasmablastic lymphoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Transformation of follicular lymphoma to plasmablastic lymphoma with c-myc gene rearrangement.
|
21088162 |
2010 |
|
Plasmablastic lymphoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Plasmablastic lymphoma with MYC translocation: evidence for a common pathway in the generation of plasmablastic features.
|
20348882 |
2010 |
|
Plasmablastic lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
These findings show that PBL is often associated with MYC/IgH rearrangements and that this finding may portend an aggressive clinical course, suggesting that cytogenetic studies should be routinely applied in cases of PBL.
|
19762538 |
2009 |