|
Retinoblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Crocin inhibits proliferation and induces apoptosis through suppressing MYCN expression in retinoblastoma.
|
30672053 |
2019 |
|
Retinoblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
These established retinoblastoma cell lines represent the most frequent types of RB1 inactivation and together with the MYCN amplification status, three classes can be distinguished: RB1<sup>mut</sup>/MYCN<sup>nonA</sup>, RB1<sup>mut</sup>/MYCN<sup>A</sup> and RB1<sup>wt</sup>/MYCN<sup>A</sup>.
|
30584916 |
2019 |
|
Retinoblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
We also discuss the subtype of retinoblastoma driven by the MYCN oncogene more commonly associated with neuroblastoma, and consider trilateral retinoblastoma, in which an intracranial tumor arises along with ocular tumors in patients with germline RB1 gene mutations.
|
29314142 |
2019 |
|
Retinoblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Moreover, MYCN was essential to retinoblastoma cell growth and tumor formation, and ectopic MYCN partially reversed the effects of MDM2 depletion, indicating that MYCN is an important MDM2 target.
|
27748758 |
2017 |
|
Retinoblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
This Rb/MYCN model recapitulates key genetic driver alterations seen in human retinoblastoma and reveals the emergence of MYCN independence in an initially MYCN-driven tumor.
|
28165337 |
2017 |
|
Retinoblastoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The functional state of pRb is inferred to be inactive due to phosphorylation of pRb in the MYCN-amplified retinoblastoma without coding sequence mutations.
|
28211617 |
2017 |
|
Retinoblastoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
This rapid, comprehensive, and sensitive method for detecting RB1 mutations and MYCN amplification can readily identify RB1 mutation carriers and thus improve the management and genetic counseling for retinoblastoma patients and their families.
|
27155049 |
2016 |
|
Retinoblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Retinoblastoma is a pediatric eye cancer associated with RB1 loss or MYCN amplification (RB1 (+/+) MYCN(A) ).
|
26288838 |
2015 |
|
Retinoblastoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Gallie and colleagues discovered that a small proportion of retinoblastomas lack RB1 mutations and had MYCN amplification [1].
|
24509483 |
2014 |
|
Retinoblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
MYCN amplification was the sole copy-number change in one RB1(+/+)MYCN(A) retinoblastoma.
|
23498719 |
2013 |
|
Retinoblastoma
|
0.100 |
Biomarker
|
disease |
LHGDN |
Our results demonstrated that some copy number changes thought to belong to early (MDM4 gain) or late stage (MYCN and E2F3 gain) of retinoblastoma are already present in retinoma at the same (for MDM4) or at lower (for MYCN and E2F3) copy number variation respect to retinoblastoma.
|
18785023 |
2008 |
|
Retinoblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our results demonstrated that some copy number changes thought to belong to early (MDM4 gain) or late stage (MYCN and E2F3 gain) of retinoblastoma are already present in retinoma at the same (for MDM4) or at lower (for MYCN and E2F3) copy number variation respect to retinoblastoma.
|
18785023 |
2008 |
|
Retinoblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
For example, MYCN amplification has long been known to occur in both retinoblastoma and neuroblastoma tumors and is strongly associated with poor prognosis in neuroblastoma.
|
17927523 |
2007 |
|
Retinoblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Other tumors associated with MYCN overexpression include retinoblastoma, small cell lung carcinoma, glioblastoma and certain embryonal tumors.
|
15975048 |
2005 |
|
Retinoblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Amplification of MYCN is frequently found in a number of advanced-stage tumours, including neuroblastoma (25%), small cell lung cancers (7%), alveolar rhabdomyosarcoma and retinoblastoma.
|
12880971 |
2003 |
|
Retinoblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Treatment with a non-lethal concentration of hydroxyurea was shown to induce the loss of the amplified N-myc gene involved in the homogenously staining region (HSR) that was found to be associated with the nuclear membrane of retinoblastoma Y79 cells.
|
12669233 |
2003 |
|
Retinoblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Overexpression of Id2 protein has thus been postulated to result in functional inactivation of retinoblastoma in MYCN-amplified neuroblastomas, offering a potential explanation for the undifferentiated and highly proliferative nature of most MYCN-amplified neuroblastomas, as well as the paucity of retinoblastoma pathway mutations observed in clinical samples.
|
12670915 |
2003 |
|
Retinoblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Although high level amplification of N-MYC is an unfavourable prognostic indicator in neuroblastoma, these data show no evidence of a correlation between amplification of N-MYC and adverse outcome in retinoblastoma.
|
12232763 |
2002 |
|
Retinoblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The DEAD box gene, DDX1, is a putative RNA helicase that is co-amplified with MYCN in a subset of retinoblastoma (RB) and neuroblastoma (NB) tumors and cell lines.
|
9694872 |
1998 |
|
Retinoblastoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
N-MYC amplification, loss of heterozygosity on the short arm of chromosome 1 and DNA ploidy in retinoblastoma.
|
8695269 |
1996 |
|
Retinoblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Previous studies have localized the DEAD box motif gene DDX1 to the same chromosome band and demonstrated coamplification of DDX1 and MYCN in two retinoblastoma cell lines.
|
8834178 |
1996 |
|
Retinoblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
A DEAD box gene (DDX1) characterized by a motif with a putative RNA helicase was found at elevated levels, with multiple copies, in a neuroblastoma and in some retinoblastoma cell lines in which the MYCN gene was amplified.
|
8834177 |
1996 |
|
Retinoblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The overexpression of N-myc gene and its protein products has been thought to be limited to cases of neuroblastoma, retinoblastoma and small cell lung carcinoma, but there is increasing evidence of its wider distribution in human tumors.
|
8669886 |
1996 |
|
Retinoblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Recently, we have shown that the novel DDX1 gene containing a DEAD box motif maps to the same chromosome band as MYCN at 2p24 and is co-amplified with MYCN in retinoblastoma cell lines.
|
7731693 |
1995 |
|
Retinoblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The human retinoblastoma cell line Y79 has multiple copies of the MYCN gene and the DEAD box gene DDXI.
|
8527386 |
1995 |