Disease: Small cell carcinoma of lung ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0149925
Disease: Small cell carcinoma of lung
Small cell carcinoma of lung 		0.100 AlteredExpression disease BEFREE MYCN overexpression was related to advanced clinical stage and shorter survival in SCLC. 31598396 2019
CUI: C0149925
Disease: Small cell carcinoma of lung
Small cell carcinoma of lung 		0.100 AlteredExpression disease BEFREE MYCN opposite strand (MYCNOS) is a gene located on the antisense strand to MYCN that encodes alternatively spliced transcripts, two of which (MYCNOS-01 and MYCNOS-02) are known to be expressed in neuroblastoma and small cell lung cancer with reciprocal regulation between MYCNOS-02 and MYCN reported for neuroblastomas. 29466962 2018
CUI: C0149925
Disease: Small cell carcinoma of lung
Small cell carcinoma of lung 		0.100 Biomarker disease BEFREE We found that <i>MYCN</i>-amplified SCLC cells were highly sensitive to a Bromodomain and Extra-Terminal domain (BET) inhibitor JQ1, which was able to inhibit N-Myc protein expression. 29156797 2017
CUI: C0149925
Disease: Small cell carcinoma of lung
Small cell carcinoma of lung 		0.100 Biomarker disease BEFREE While MYC shares major features with its paralogs MYCN and MYCL, the sensitivity to Aurora kinase inhibitors is unique for MYC-driven SCLC. 28737478 2017
CUI: C0149925
Disease: Small cell carcinoma of lung
Small cell carcinoma of lung 		0.100 Biomarker disease BEFREE Inhibitors of PLK1 preferentially induce potent apoptosis of MYCN-amplified tumor cells from neuroblastoma and small cell lung cancer and synergistically potentiate the therapeutic efficacies of Bcl2 antagonists. 27773673 2016
CUI: C0149925
Disease: Small cell carcinoma of lung
Small cell carcinoma of lung 		0.100 Biomarker disease BEFREE The importance of ASCL1 as a potential driver oncogene in SCLC is further underscored by the observation that ASCL1 is overexpressed in >50% of SCLC specimens, an extent greater than that observed for other putative oncogenes (MYC, MYCN, and SOX2) previously implicated in SCLC. 26253517 2015
CUI: C0149925
Disease: Small cell carcinoma of lung
Small cell carcinoma of lung 		0.100 Biomarker disease BEFREE Whereas RB1 inactivation, intact CDKN2A/p16, and normal CCND1/Cyclin D1 status are hallmarks of SCLC, activation or amplification of any of the three Myc genes (MYC, MYCL1, and MYCN) clearly differentiated cell line sensitivity within the SCLC panel. 22222631 2012
CUI: C0149925
Disease: Small cell carcinoma of lung
Small cell carcinoma of lung 		0.100 GeneticVariation disease BEFREE We identified localized DNA amplifications corresponding to oncogenes known to be amplified in SCLC, including MYC (8q24), MYCN (2p24) and MYCL1 (1p34). 16116477 2006
CUI: C0149925
Disease: Small cell carcinoma of lung
Small cell carcinoma of lung 		0.100 AlteredExpression disease BEFREE Candidate genes for these amplifications include the l-MYC (1p32) and n-MYC (2p24.1) oncogenes, which have been previously found to be overexpressed in SCLC. 11494021 2001
CUI: C0149925
Disease: Small cell carcinoma of lung
Small cell carcinoma of lung 		0.100 Biomarker disease BEFREE The N-myc gene was amplified around 60-fold in H-69 and 40-fold in SBC-4 cells compared with placenta tissues, and these two cell lines were more resistant to CDDP than the nine other SCLC cell lines without N-myc amplification. 8784478 1996
CUI: C0149925
Disease: Small cell carcinoma of lung
Small cell carcinoma of lung 		0.100 AlteredExpression disease BEFREE The overexpression of N-myc gene and its protein products has been thought to be limited to cases of neuroblastoma, retinoblastoma and small cell lung carcinoma, but there is increasing evidence of its wider distribution in human tumors. 8669886 1996
CUI: C0149925
Disease: Small cell carcinoma of lung
Small cell carcinoma of lung 		0.100 AlteredExpression disease BEFREE Oncogene expression in small-cell lung cancer cell lines and a testicular germ-cell tumor: activation of the N-myc gene and decreased RB mRNA. 2545635 1989
CUI: C0149925
Disease: Small cell carcinoma of lung
Small cell carcinoma of lung 		0.100 GeneticVariation disease BEFREE In a small-cell lung carcinoma (SCLC) tumor specimen as well as in 3 cell lines derived from SCLC biopsies obtained from the same patient at successive times during the clinical course, either the N-myc gene or the c-myc gene appeared to be amplified and expressed. 2545636 1989
CUI: C0149925
Disease: Small cell carcinoma of lung
Small cell carcinoma of lung 		0.100 AlteredExpression disease BEFREE Our results confirm that cytogenetically visible deletions of 3p are often present in cell lines established from patients with SCLC, and that mutually exclusive c-, L-, or N-myc gene amplification is also a common event in SCLC cell lines. 2830010 1988
CUI: C0149925
Disease: Small cell carcinoma of lung
Small cell carcinoma of lung 		0.100 GeneticVariation disease BEFREE Amplification of the N-myc gene has been reported in a number of tumour types including neuroblastoma, retinoblastoma and small cell lung carcinoma. 2834684 1988
CUI: C0149925
Disease: Small cell carcinoma of lung
Small cell carcinoma of lung 		0.100 Biomarker disease BEFREE We have found that 6 of 31 independently derived human small-cell lung cancer (SCLC) cell lines have 5- to 170-fold amplified N-myc gene sequences. 2869482 1986
CUI: C0149925
Disease: Small cell carcinoma of lung
Small cell carcinoma of lung 		0.100 Biomarker disease BEFREE SCLC cell lines with amplified L-myc sequences express L-myc-derived transcripts not seen in SCLC with amplified c-myc or N-myc genes. 2997622 1985