MYH10, myosin heavy chain 10, 4628

N. diseases: 31; N. variants: 1
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0003486
Disease: Aortic Aneurysm
Aortic Aneurysm 		0.010 Biomarker disease BEFREE In summary, using weighted gene coexpression analysis, our study indicates that CLU, DES, MYH10, and FBLN5 were identified and validated to be related to TAA and might be candidate biomarkers or therapeutic targets for TAA. 31489966 2020
CUI: C0178874
Disease: Tumor Progression
Tumor Progression 		0.010 Biomarker phenotype BEFREE Their less responsive sister paralogs-myosin IIB (MYH10), α-actinin 1, and filamin A-had lower expression differential or disappeared with cancer progression. 31358530 2019
CUI: C0595921
Disease: Intraocular pressure disorder
Intraocular pressure disorder 		0.010 Biomarker disease BEFREE CK-666 and shMyo10-silencing lentivirus caused a significant reduction in outflow rates in anterior segment perfusion culture, an ex vivo method to study intraocular pressure regulation. 30807639 2019
CUI: C0010520
Disease: Cyanosis
Cyanosis 		0.010 GeneticVariation phenotype BEFREE Myh10 mutant pups exhibit cyanosis and respiratory distress, and die shortly after birth from differentiation defects in alveolar epithelium and mesenchyme. 30389913 2018
CUI: C0017638
Disease: Glioma
Glioma 		0.010 Biomarker disease BEFREE This study aimed to investigate the effects of the MYH10 gene on normal human glial cells and glioma cell lines in vitro, by gene silencing, and to determine the signaling pathways involved. 30552850 2018
CUI: C0024115
Disease: Lung diseases
Lung diseases 		0.010 Biomarker group BEFREE Myh10 deficiency leads to defective extracellular matrix remodeling and pulmonary disease. 30389913 2018
CUI: C0025202
Disease: melanoma
melanoma 		0.010 Biomarker disease BEFREE Myosin X is required for efficient melanoblast migration and melanoma initiation and metastasis. 29993000 2018
CUI: C0034067
Disease: Pulmonary Emphysema
Pulmonary Emphysema 		0.010 Biomarker disease BEFREE Altogether, our findings reveal critical roles for Myh10 in alveologenesis at least in part via the regulation of ECM remodeling, which may contribute to the pathogenesis of emphysema. 30389913 2018
CUI: C0149782
Disease: Squamous cell carcinoma of lung
Squamous cell carcinoma of lung 		0.010 AlteredExpression disease BEFREE Among these the non-muscle myosin 10 (MYO10) showed the highest upregulation in a LUSC patient cohort of the Cancer Genome Atlas (TCGA). 29934580 2018
CUI: C0476273
Disease: Respiratory distress
Respiratory distress 		0.010 GeneticVariation phenotype BEFREE Myh10 mutant pups exhibit cyanosis and respiratory distress, and die shortly after birth from differentiation defects in alveolar epithelium and mesenchyme. 30389913 2018
CUI: C0020295
Disease: Hydronephrosis
Hydronephrosis 		0.010 Biomarker disease BEFREE Here we report that ND/UB lineage-specific deletion of Myh9/Myh10 in mice caused severe hydroureter/hydronephrosis at birth. 28478097 2017
CUI: C0021053
Disease: Immune System Diseases
Immune System Diseases 		0.010 Biomarker group BEFREE The persistence of MYH10 expression in platelets is a surrogate marker for FLI1 and RUNX1 defects. 27450272 2017
CUI: C0521620
Disease: Dilatation of ureter
Dilatation of ureter 		0.010 Biomarker disease BEFREE Here we report that ND/UB lineage-specific deletion of Myh9/Myh10 in mice caused severe hydroureter/hydronephrosis at birth. 28478097 2017
CUI: C0741916
Disease: Cardiac defects
Cardiac defects 		0.010 GeneticVariation group BEFREE Complementation testing confirmed that the Myh10 mutation causes the EHC phenotype. 29084269 2017
CUI: C1510586
Disease: Autism Spectrum Disorders
Autism Spectrum Disorders 		0.010 Biomarker disease BEFREE We identify three mosaic missense and likely-gene disrupting mutations in genes previously implicated in ASD (KMT2C, NCKAP1, and MYH10) in probands but none in siblings. 27632392 2016
CUI: C0005818
Disease: Blood Platelet Disorders
Blood Platelet Disorders 		0.010 Biomarker group BEFREE We propose MYH10 detection as a new and simple tool to identify inherited platelet disorders and myeloid neoplasms with abnormalities in RUNX1 and its associated proteins. 22677128 2012
CUI: C0021390
Disease: Inflammatory Bowel Diseases
Inflammatory Bowel Diseases 		0.010 Biomarker group BEFREE The MCC gene is methylated in up to 6/16 of inflammatory bowel disease-associated tissue specimens, and myosin-10 and valosin-containing protein were identified as MCC-interacting proteins. 22213290 2012
CUI: C0023467
Disease: Leukemia, Myelocytic, Acute
Leukemia, Myelocytic, Acute 		0.010 Biomarker disease BEFREE Here we demonstrate that runx1 deletion in mice induces the persistence of MYH10 in platelets, and a similar persistence was observed in platelets of patients with constitutional (familial platelet disorder/acute myeloid leukemia) or acquired (chronic myelomonocytic leukemia) RUNX1 mutations. 22677128 2012
CUI: C0023480
Disease: Leukemia, Myelomonocytic, Chronic
Leukemia, Myelomonocytic, Chronic 		0.010 Biomarker disease BEFREE Here we demonstrate that runx1 deletion in mice induces the persistence of MYH10 in platelets, and a similar persistence was observed in platelets of patients with constitutional (familial platelet disorder/acute myeloid leukemia) or acquired (chronic myelomonocytic leukemia) RUNX1 mutations. 22677128 2012
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.010 Biomarker group BEFREE We propose MYH10 detection as a new and simple tool to identify inherited platelet disorders and myeloid neoplasms with abnormalities in RUNX1 and its associated proteins. 22677128 2012
CUI: C0040034
Disease: Thrombocytopenia
Thrombocytopenia 		0.010 Biomarker phenotype BEFREE MYH10 was also detected in platelets of patients with the Paris-Trousseau syndrome, a thrombocytopenia related to the deletion of the transcription factor FLI1 that forms a complex with RUNX1 to regulate megakaryopoiesis, whereas MYH10 persistence was not observed in other inherited forms of thrombocytopenia. 22677128 2012
CUI: C0349639
Disease: Juvenile Myelomonocytic Leukemia
Juvenile Myelomonocytic Leukemia 		0.010 Biomarker disease BEFREE Here we demonstrate that runx1 deletion in mice induces the persistence of MYH10 in platelets, and a similar persistence was observed in platelets of patients with constitutional (familial platelet disorder/acute myeloid leukemia) or acquired (chronic myelomonocytic leukemia) RUNX1 mutations. 22677128 2012
CUI: C0795841
Disease: Jacobsen Distal 11q Deletion Syndrome
Jacobsen Distal 11q Deletion Syndrome 		0.010 Biomarker disease BEFREE MYH10 was also detected in platelets of patients with the Paris-Trousseau syndrome, a thrombocytopenia related to the deletion of the transcription factor FLI1 that forms a complex with RUNX1 to regulate megakaryopoiesis, whereas MYH10 persistence was not observed in other inherited forms of thrombocytopenia. 22677128 2012
CUI: C1956093
Disease: Paris-Trousseau Thrombocytopenia
Paris-Trousseau Thrombocytopenia 		0.010 Biomarker disease BEFREE MYH10 was also detected in platelets of patients with the Paris-Trousseau syndrome, a thrombocytopenia related to the deletion of the transcription factor FLI1 that forms a complex with RUNX1 to regulate megakaryopoiesis, whereas MYH10 persistence was not observed in other inherited forms of thrombocytopenia. 22677128 2012
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast 		0.020 AlteredExpression disease BEFREE Elevated expression of myosin X in tumours contributes to breast cancer aggressiveness and metastasis. 24921915 2014