MYH10, myosin heavy chain 10, 4628

N. diseases: 31; N. variants: 1
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast 		0.020 AlteredExpression disease BEFREE Mutant p53-associated myosin-X upregulation promotes breast cancer invasion and metastasis. 24487586 2014
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma 		0.020 AlteredExpression disease BEFREE Mutant p53-associated myosin-X upregulation promotes breast cancer invasion and metastasis. 24487586 2014
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma 		0.020 AlteredExpression disease BEFREE Elevated expression of myosin X in tumours contributes to breast cancer aggressiveness and metastasis. 24921915 2014
CUI: C1269955
Disease: Tumor Cell Invasion
Tumor Cell Invasion 		0.030 AlteredExpression phenotype BEFREE MYH10 expression was down-regulated following siMYH10 plasmid interference, which also inhibited glioma cell migration and invasion. 30552850 2018
CUI: C1269955
Disease: Tumor Cell Invasion
Tumor Cell Invasion 		0.030 Biomarker phenotype BEFREE These data support the conclusion that MYH10‑mediated cell migration and invasion act in conjunction with PIF to promote the trophoblast invasion procedure. 29286136 2018
CUI: C1269955
Disease: Tumor Cell Invasion
Tumor Cell Invasion 		0.030 AlteredExpression phenotype BEFREE Mutant p53-associated myosin-X upregulation promotes breast cancer invasion and metastasis. 24487586 2014
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis 		0.040 Biomarker phenotype BEFREE Myosin X is required for efficient melanoblast migration and melanoma initiation and metastasis. 29993000 2018
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis 		0.040 Biomarker phenotype BEFREE BACKGROUND The myosin heavy chain 10 or MYH10 gene encodes non-muscle myosin II B (NM IIB), and is involved in tumor cell migration, invasion, extracellular matrix (ECM) production, and epithelial-mesenchymal transition (EMT). 30552850 2018
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis 		0.040 AlteredExpression phenotype BEFREE Elevated expression of myosin X in tumours contributes to breast cancer aggressiveness and metastasis. 24921915 2014
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis 		0.040 AlteredExpression phenotype BEFREE Mutant p53-associated myosin-X upregulation promotes breast cancer invasion and metastasis. 24487586 2014
CUI: C2936786
Disease: Aqueductal Stenosis
Aqueductal Stenosis 		0.300 Biomarker disease GENOMICS_ENGLAND Whole-exome sequencing in the evaluation of fetal structural anomalies: a prospective cohort study. 30712878 2019
CUI: C0017668
Disease: Focal glomerulosclerosis
Focal glomerulosclerosis 		0.300 Biomarker disease CTD_human Glomerular nonmuscle-type myosin heavy-chain isoform gene expression in glomerulosclerosis. 9678433 1998
CUI: C0086432
Disease: Hyalinosis, Segmental Glomerular
Hyalinosis, Segmental Glomerular 		0.300 Biomarker disease CTD_human Glomerular nonmuscle-type myosin heavy-chain isoform gene expression in glomerulosclerosis. 9678433 1998