MYH10, myosin heavy chain 10, 4628

N. diseases: 31; N. variants: 1
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C2936786
Disease: Aqueductal Stenosis
Aqueductal Stenosis 		0.300 Biomarker disease GENOMICS_ENGLAND Whole-exome sequencing in the evaluation of fetal structural anomalies: a prospective cohort study. 30712878 2019
CUI: C0017668
Disease: Focal glomerulosclerosis
Focal glomerulosclerosis 		0.300 Biomarker disease CTD_human Glomerular nonmuscle-type myosin heavy-chain isoform gene expression in glomerulosclerosis. 9678433 1998
CUI: C0086432
Disease: Hyalinosis, Segmental Glomerular
Hyalinosis, Segmental Glomerular 		0.300 Biomarker disease CTD_human Glomerular nonmuscle-type myosin heavy-chain isoform gene expression in glomerulosclerosis. 9678433 1998
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis 		0.040 Biomarker phenotype BEFREE Myosin X is required for efficient melanoblast migration and melanoma initiation and metastasis. 29993000 2018
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis 		0.040 Biomarker phenotype BEFREE BACKGROUND The myosin heavy chain 10 or MYH10 gene encodes non-muscle myosin II B (NM IIB), and is involved in tumor cell migration, invasion, extracellular matrix (ECM) production, and epithelial-mesenchymal transition (EMT). 30552850 2018
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis 		0.040 AlteredExpression phenotype BEFREE Elevated expression of myosin X in tumours contributes to breast cancer aggressiveness and metastasis. 24921915 2014
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis 		0.040 AlteredExpression phenotype BEFREE Mutant p53-associated myosin-X upregulation promotes breast cancer invasion and metastasis. 24487586 2014
CUI: C1269955
Disease: Tumor Cell Invasion
Tumor Cell Invasion 		0.030 AlteredExpression phenotype BEFREE MYH10 expression was down-regulated following siMYH10 plasmid interference, which also inhibited glioma cell migration and invasion. 30552850 2018
CUI: C1269955
Disease: Tumor Cell Invasion
Tumor Cell Invasion 		0.030 Biomarker phenotype BEFREE These data support the conclusion that MYH10‑mediated cell migration and invasion act in conjunction with PIF to promote the trophoblast invasion procedure. 29286136 2018
CUI: C1269955
Disease: Tumor Cell Invasion
Tumor Cell Invasion 		0.030 AlteredExpression phenotype BEFREE Mutant p53-associated myosin-X upregulation promotes breast cancer invasion and metastasis. 24487586 2014
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast 		0.020 AlteredExpression disease BEFREE Elevated expression of myosin X in tumours contributes to breast cancer aggressiveness and metastasis. 24921915 2014
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast 		0.020 AlteredExpression disease BEFREE Mutant p53-associated myosin-X upregulation promotes breast cancer invasion and metastasis. 24487586 2014
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma 		0.020 AlteredExpression disease BEFREE Mutant p53-associated myosin-X upregulation promotes breast cancer invasion and metastasis. 24487586 2014
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma 		0.020 AlteredExpression disease BEFREE Elevated expression of myosin X in tumours contributes to breast cancer aggressiveness and metastasis. 24921915 2014
CUI: C0003486
Disease: Aortic Aneurysm
Aortic Aneurysm 		0.010 Biomarker disease BEFREE In summary, using weighted gene coexpression analysis, our study indicates that CLU, DES, MYH10, and FBLN5 were identified and validated to be related to TAA and might be candidate biomarkers or therapeutic targets for TAA. 31489966 2020
CUI: C0178874
Disease: Tumor Progression
Tumor Progression 		0.010 Biomarker phenotype BEFREE Their less responsive sister paralogs-myosin IIB (MYH10), α-actinin 1, and filamin A-had lower expression differential or disappeared with cancer progression. 31358530 2019
CUI: C0595921
Disease: Intraocular pressure disorder
Intraocular pressure disorder 		0.010 Biomarker disease BEFREE CK-666 and shMyo10-silencing lentivirus caused a significant reduction in outflow rates in anterior segment perfusion culture, an ex vivo method to study intraocular pressure regulation. 30807639 2019
CUI: C0010520
Disease: Cyanosis
Cyanosis 		0.010 GeneticVariation phenotype BEFREE Myh10 mutant pups exhibit cyanosis and respiratory distress, and die shortly after birth from differentiation defects in alveolar epithelium and mesenchyme. 30389913 2018
CUI: C0017638
Disease: Glioma
Glioma 		0.010 Biomarker disease BEFREE This study aimed to investigate the effects of the MYH10 gene on normal human glial cells and glioma cell lines in vitro, by gene silencing, and to determine the signaling pathways involved. 30552850 2018
CUI: C0024115
Disease: Lung diseases
Lung diseases 		0.010 Biomarker group BEFREE Myh10 deficiency leads to defective extracellular matrix remodeling and pulmonary disease. 30389913 2018
CUI: C0025202
Disease: melanoma
melanoma 		0.010 Biomarker disease BEFREE Myosin X is required for efficient melanoblast migration and melanoma initiation and metastasis. 29993000 2018
CUI: C0034067
Disease: Pulmonary Emphysema
Pulmonary Emphysema 		0.010 Biomarker disease BEFREE Altogether, our findings reveal critical roles for Myh10 in alveologenesis at least in part via the regulation of ECM remodeling, which may contribute to the pathogenesis of emphysema. 30389913 2018
CUI: C0149782
Disease: Squamous cell carcinoma of lung
Squamous cell carcinoma of lung 		0.010 AlteredExpression disease BEFREE Among these the non-muscle myosin 10 (MYO10) showed the highest upregulation in a LUSC patient cohort of the Cancer Genome Atlas (TCGA). 29934580 2018
CUI: C0476273
Disease: Respiratory distress
Respiratory distress 		0.010 GeneticVariation phenotype BEFREE Myh10 mutant pups exhibit cyanosis and respiratory distress, and die shortly after birth from differentiation defects in alveolar epithelium and mesenchyme. 30389913 2018
CUI: C0020295
Disease: Hydronephrosis
Hydronephrosis 		0.010 Biomarker disease BEFREE Here we report that ND/UB lineage-specific deletion of Myh9/Myh10 in mice caused severe hydroureter/hydronephrosis at birth. 28478097 2017