|
Cerebrovascular accident
|
0.480 |
Biomarker
|
group |
BEFREE |
AF and stroke are related and ZNF566, PDZK1IP1, ZFHX3, and PITX2 genes are significantly associated with novel biomarkers involved in AF-related stroke.
|
30760287 |
2019 |
|
Cerebrovascular accident
|
0.480 |
GeneticVariation
|
group |
GWASCAT |
Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes.
|
29531354 |
2018 |
|
Cerebrovascular accident
|
0.480 |
Biomarker
|
group |
CTD_human |
Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes.
|
29531354 |
2018 |
|
Cerebrovascular accident
|
0.480 |
Biomarker
|
group |
BEFREE |
Our results also supported robust associations with ischaemic stroke for four other loci that have been reported in previous studies, including PITX2 (first stage OR 1·39, 1·29-1·49, p=3·26 × 10<sup>-19</sup>; joint OR 1·37, 1·30-1·45, p=2·79 × 10<sup>-32</sup>) and ZFHX3 (first stage OR 1·19, 1·11-1·27, p=2·93 × 10<sup>-7</sup>; joint OR 1·17, 1·11-1·23, p=2·29 × 10<sup>-10</sup>) for cardioembolic stroke, and HDAC9 (first stage OR 1·29, 1·18-1·42, p=3·50 × 10<sup>-8</sup>; joint OR 1·24, 1·15-1·33, p=4·52 × 10<sup>-9</sup>) for large artery atherosclerosis stroke.
|
26708676 |
2016 |
|
Cerebrovascular accident
|
0.480 |
GeneticVariation
|
group |
GWASCAT |
Pleiotropic Meta-Analyses of Longitudinal Studies Discover Novel Genetic Variants Associated with Age-Related Diseases.
|
27790247 |
2016 |
|
Cerebrovascular accident
|
0.480 |
GeneticVariation
|
group |
BEFREE |
In our study we are focusing on a possible correlation between detection of atrial fibrillation by an implantable ECG recorder, and PITX2 and/or ZFHX3 gene mutations in cryptogenic stroke/TIA patients.
|
26631084 |
2015 |
|
Cerebrovascular accident
|
0.480 |
Biomarker
|
group |
BEFREE |
Replication of protein-coding variants in candidate genes was observed for 2 previously reported GWAS associations: ZFHX3 (cardioembolic stroke) and ABCA1 (large-vessel stroke).
|
25961151 |
2015 |
|
Cerebrovascular accident
|
0.480 |
GeneticVariation
|
group |
BEFREE |
Four of 7 previously reported ischemic stroke loci (PITX2, HDAC9, CDKN2A/CDKN2B, and ZFHX3) were nominally associated (P<0.05) with stroke in COMPASS.
|
26089329 |
2015 |
|
Cerebrovascular accident
|
0.480 |
Biomarker
|
group |
BEFREE |
We verified previous associations for cardioembolic stroke near PITX2 (p=2·8×10(-16)) and ZFHX3 (p=2·28×10(-8)), and for large-vessel stroke at a 9p21 locus (p=3·32×10(-5)) and HDAC9 (p=2·03×10(-12)).
|
23041239 |
2012 |
|
Cerebrovascular accident
|
0.480 |
GeneticVariation
|
group |
GWASDB |
Genetic risk factors for ischaemic stroke and its subtypes (the METASTROKE collaboration): a meta-analysis of genome-wide association studies.
|
23041239 |
2012 |
|
Cerebrovascular accident
|
0.480 |
Biomarker
|
group |
BEFREE |
Each of these underlying pathologies may have a specific genetic architecture.Previous genome-wide association studies (GWAS) showed association of variants near PITX2 and ZFHX3 with atrial fibrillation and stroke.
|
22776031 |
2012 |
|
Cerebrovascular accident
|
0.480 |
GeneticVariation
|
group |
GWASCAT |
Genetic risk factors for ischaemic stroke and its subtypes (the METASTROKE collaboration): a meta-analysis of genome-wide association studies.
|
23041239 |
2012 |
|
Cerebrovascular accident
|
0.480 |
Biomarker
|
group |
BEFREE |
We replicated previous associations for cardioembolic stroke near PITX2 and ZFHX3 and for large vessel stroke at a 9p21 locus.
|
22306652 |
2012 |