MYL4, myosin light chain 4, 4635

N. diseases: 26; N. variants: 5
Disease: Atrial Fibrillation ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0004238
Disease: Atrial Fibrillation
Atrial Fibrillation 		0.040 GeneticVariation disease BEFREE A Metastable Atrial State Underlies The Primary Genetic Substrate for MYL4 Mutation-Associated Atrial Fibrillation. 31735076 2020
CUI: C0004238
Disease: Atrial Fibrillation
Atrial Fibrillation 		0.040 GeneticVariation disease BEFREE Rs4968309 in Myosin Light Chain 4 (MYL4) Associated With Atrial Fibrillation Onset and Predicts Clinical Outcomes After Catheter Ablation in Atrial Fibrillation Patients Without Structural Heart Disease. 31406021 2019
CUI: C0004238
Disease: Atrial Fibrillation
Atrial Fibrillation 		0.040 GeneticVariation disease BEFREE We discovered a rare frameshift deletion in the myosin MYL4 gene (c.234delC) that associates with early-onset AF under a recessive mode of inheritance (allelic frequency = 0.58%). 27742809 2017
CUI: C0004238
Disease: Atrial Fibrillation
Atrial Fibrillation 		0.040 GeneticVariation disease BEFREE In zebrafish, mutant MYL4 leads to disruption of sarcomeric structure, atrial enlargement and electrical abnormalities associated with human AF. 27066836 2016