Celiac Disease
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
No MYO9B variants or MYO9B haplotypes were found associated with CD, either before or after stratification of the patients for the human leucocyte antigen (HLA)-DQ2-positive risk factor.
|
17176439 |
2006 |
Celiac Disease
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
To evaluate whether single nucleotide polymorphisms (SNPs) tagging the MYO9B susceptibility haplotype and the IBD5 locus (5q31-33) are involved in CD predisposition, we performed case-control and family-based analyses.
|
17667713 |
2007 |
Celiac Disease
|
0.600 |
Biomarker
|
disease |
BEFREE |
We show that both MYO9B and HLA-DQ2 homozygosity might be involved in the prognosis of CD and the chance of developing RCD II and EATL.
|
17967566 |
2007 |
Celiac Disease
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The MYO9B gene rs 2305764 polymorphism is not associated to coeliac disease in coeliac children from Southern Italy.
|
17267307 |
2007 |
Celiac Disease
|
0.600 |
Biomarker
|
disease |
BEFREE |
This might also be true for coeliac disease, a chronic inflammatory disorder of the gastrointestinal system, which shares two linkage regions with inflammatory bowel disease: on chromosome 5q31 (CELIAC2 and IBD5) and 19p13 (CELIAC4 and IBD6).
|
16835590 |
2006 |
Celiac Disease
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Besides the well known involvement of the HLA class II histocompatibility antigen (HLA)-DQ2.5 and -DQ8 heterodimers (encoded by particular combinations of the HLA-DQA1 and -DQB1 gene) in CD and the minor contribution of the CTLA-4 gene, recently the myosin IXB (MYO9B) gene has also been found to be genetically associated.
|
17438672 |
2006 |
Celiac Disease
|
0.600 |
Biomarker
|
disease |
BEFREE |
Is MYO9B the missing link between schizophrenia and celiac disease?
|
17948900 |
2008 |
Celiac Disease
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Based on this review, we performed genetic analysis of the MYO9B gene and the IL-2/IL-21 locus by genotyping SNPs that have been previously associated with coeliac disease or schizophrenia in 223 families, 108 unrelated individuals with schizophrenia and 120 controls.
|
21688385 |
2011 |
Celiac Disease
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
However, for the first time, rs2305767 MYO9B was revealed to have a strong association with TS (X<sup>2 </sup> = 58.6, p = .0001, and OR = 10.44 [95% C = 5.51-19.80]), supporting a high level of predisposition to CD among TS patients.
|
28627089 |
2017 |
Celiac Disease
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
To address this, we performed an association study of a Norwegian IBD cohort (149 patients with Crohn's disease, 308 patients with ulcerative colitis and 562 healthy controls) using SNPs, which tagged the celiac disease associated MYO9B haplotype.
|
16948647 |
2006 |
Celiac Disease
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Genetic variation in MYO9B does not have a major effect on coeliac disease susceptibility in the UK population.
|
16423886 |
2006 |
Celiac Disease
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Polymorphisms in the 3' region of myosin IXB (Myo9B) are associated with chronic inflammatory gastrointestinal disorders like celiac disease and ulcerative colitis, assuming that variation in Myo9B influences the intestinal permeability.
|
22954106 |
2012 |
Celiac Disease
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Various genes may influence intestinal barrier function, including MAGI2, MYO9B, and PARD3, which are associated with celiac disease.
|
20096742 |
2010 |
Celiac Disease
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
We have investigated how relevant regions contribute to CD susceptibility: CELIAC3 (CD28/CTLA4/ICOS region on 2q33) and CELIAC4 (19p13) as well as the tumour necrosis factor alpha (TNF-alpha) and the linfotoxin loci by case-control and association analyses.
|
17767555 |
2007 |
Celiac Disease
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
This meta-analysis indicates that MYO9B gene polymorphisms might be not associated with CD susceptibility in Caucasians.
|
27219348 |
2016 |
Celiac Disease
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Myosin IXB variant increases the risk of celiac disease and points toward a primary intestinal barrier defect.
|
16282976 |
2005 |
Celiac Disease
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Lack of reproducibility could be explained by no or negligible contribution of MYO9B to the genetic predisposition to CD in the Swedish/Norwegian population.
|
16720215 |
2006 |
Celiac Disease
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
our findings suggest that genetic variation MYO9B gene is associated with CD, as a protective or a risk factor depending on the polymorphism studied.
|
23368647 |
2012 |
Celiac Disease
|
0.600 |
Biomarker
|
disease |
BEFREE |
In conclusion, MYO9B is not involved in CD susceptibility in the Italian population.
|
16943798 |
2006 |
Celiac Disease
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
This suggests that genetic variation in MYO9B is associated with CD, SLE, and RA and that MYO9B is a general risk factor for autoimmunity.
|
17584584 |
2007 |
Celiac Disease
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
To date, seven studies have provided evidence for an association between the gene encoding for myosin IXB (MYO9B) and celiac disease (CD), and inflammatory bowel diseases, including single nucleotide polymorphisms (SNPs) rs2305767, rs1457092, and rs2305764.
|
20303373 |
2010 |
Celiac Disease
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Common variation in MYO9B was associated with susceptibility to inflammatory bowel disease in all 3 cohorts examined (most associated SNP, rs1545620; meta-analysis P = 1.9 x 10(-6); odds ratio, 1.2), with the same alleles showing association as reported for celiac disease.
|
17087940 |
2006 |
Celiac Disease
|
0.600 |
Biomarker
|
disease |
BEFREE |
Therefore, more detailed genetic and functional studies are required to characterise the role of the myosin IXB gene in both coeliac disease and dermatitis herpetiformis.
|
18077767 |
2008 |
Schizophrenia
|
0.330 |
GeneticVariation
|
disease |
BEFREE |
Based on this review, we performed genetic analysis of the MYO9B gene and the IL-2/IL-21 locus by genotyping SNPs that have been previously associated with coeliac disease or schizophrenia in 223 families, 108 unrelated individuals with schizophrenia and 120 controls.
|
21688385 |
2011 |
Schizophrenia
|
0.330 |
Biomarker
|
disease |
BEFREE |
The present study was then undertaken to examine whether the association of MYO9B with schizophrenia could be replicated in a Chinese population.
|
25710847 |
2015 |