MYO9B, myosin IXB, 4650

N. diseases: 65; N. variants: 29
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0007570
Disease: Celiac Disease
Celiac Disease 		0.600 Biomarker disease CTD_human
CUI: C1857847
Disease: CELIAC DISEASE, SUSCEPTIBILITY TO, 4
CELIAC DISEASE, SUSCEPTIBILITY TO, 4 		0.100 SusceptibilityMutation phenotype CLINVAR
CUI: C0013371
Disease: Shigella Infections
Shigella Infections 		0.010 AlteredExpression group BEFREE The recruitment pattern resembled that of rhoC or ezrin, but not rhoA, rac or CDC42, while in vitro GAP activity of myr5 was similar for rhoA, B or C. Analysis of myr5 mutants suggested that GTPase- or ATP-binding activites are not required for Shigella-induced recruitment of this atypical myosin to the bacterial entry site. 11207612 2000
CUI: C0007570
Disease: Celiac Disease
Celiac Disease 		0.600 GeneticVariation disease LHGDN Myosin IXB variant increases the risk of celiac disease and points toward a primary intestinal barrier defect. 16282976 2005
CUI: C0007570
Disease: Celiac Disease
Celiac Disease 		0.600 GeneticVariation disease BEFREE Myosin IXB variant increases the risk of celiac disease and points toward a primary intestinal barrier defect. 16282976 2005
CUI: C0007570
Disease: Celiac Disease
Celiac Disease 		0.600 GeneticVariation disease BEFREE Genetic variation in MYO9B does not have a major effect on coeliac disease susceptibility in the UK population. 16423886 2006
CUI: C0007570
Disease: Celiac Disease
Celiac Disease 		0.600 GeneticVariation disease LHGDN Lack of reproducibility could be explained by no or negligible contribution of MYO9B to the genetic predisposition to CD in the Swedish/Norwegian population. 16720215 2006
CUI: C0007570
Disease: Celiac Disease
Celiac Disease 		0.600 GeneticVariation disease BEFREE Lack of reproducibility could be explained by no or negligible contribution of MYO9B to the genetic predisposition to CD in the Swedish/Norwegian population. 16720215 2006
CUI: C0007570
Disease: Celiac Disease
Celiac Disease 		0.600 Biomarker disease BEFREE This might also be true for coeliac disease, a chronic inflammatory disorder of the gastrointestinal system, which shares two linkage regions with inflammatory bowel disease: on chromosome 5q31 (CELIAC2 and IBD5) and 19p13 (CELIAC4 and IBD6). 16835590 2006
CUI: C0021390
Disease: Inflammatory Bowel Diseases
Inflammatory Bowel Diseases 		0.100 Biomarker group BEFREE This might also be true for coeliac disease, a chronic inflammatory disorder of the gastrointestinal system, which shares two linkage regions with inflammatory bowel disease: on chromosome 5q31 (CELIAC2 and IBD5) and 19p13 (CELIAC4 and IBD6). 16835590 2006
CUI: C0007570
Disease: Celiac Disease
Celiac Disease 		0.600 Biomarker disease BEFREE In conclusion, MYO9B is not involved in CD susceptibility in the Italian population. 16943798 2006
CUI: C0007570
Disease: Celiac Disease
Celiac Disease 		0.600 GeneticVariation disease LHGDN In conclusion, MYO9B is not involved in CD susceptibility in the Italian population. 16943798 2006
CUI: C0007570
Disease: Celiac Disease
Celiac Disease 		0.600 GeneticVariation disease BEFREE To address this, we performed an association study of a Norwegian IBD cohort (149 patients with Crohn's disease, 308 patients with ulcerative colitis and 562 healthy controls) using SNPs, which tagged the celiac disease associated MYO9B haplotype. 16948647 2006
CUI: C0021390
Disease: Inflammatory Bowel Diseases
Inflammatory Bowel Diseases 		0.100 Biomarker group BEFREE Our results failed to support the notion that MYO9B is a susceptibility gene in IBD. 16948647 2006
CUI: C0007570
Disease: Celiac Disease
Celiac Disease 		0.600 GeneticVariation disease BEFREE Common variation in MYO9B was associated with susceptibility to inflammatory bowel disease in all 3 cohorts examined (most associated SNP, rs1545620; meta-analysis P = 1.9 x 10(-6); odds ratio, 1.2), with the same alleles showing association as reported for celiac disease. 17087940 2006
CUI: C0021390
Disease: Inflammatory Bowel Diseases
Inflammatory Bowel Diseases 		0.100 GeneticVariation group LHGDN Unlike previous variants (in other genes) reported to predispose to inflammatory bowel disease, the association at MYO9B was considerably stronger with ulcerative colitis, although weaker association with Crohn's disease also was observed. 17087940 2006
CUI: C0021390
Disease: Inflammatory Bowel Diseases
Inflammatory Bowel Diseases 		0.100 GeneticVariation group BEFREE Unlike previous variants (in other genes) reported to predispose to inflammatory bowel disease, the association at MYO9B was considerably stronger with ulcerative colitis, although weaker association with Crohn's disease also was observed. 17087940 2006
CUI: C0009324
Disease: Ulcerative Colitis
Ulcerative Colitis 		0.080 GeneticVariation disease LHGDN Unlike previous variants (in other genes) reported to predispose to inflammatory bowel disease, the association at MYO9B was considerably stronger with ulcerative colitis, although weaker association with Crohn's disease also was observed. 17087940 2006
CUI: C0009324
Disease: Ulcerative Colitis
Ulcerative Colitis 		0.080 GeneticVariation disease BEFREE Unlike previous variants (in other genes) reported to predispose to inflammatory bowel disease, the association at MYO9B was considerably stronger with ulcerative colitis, although weaker association with Crohn's disease also was observed. 17087940 2006
CUI: C0010346
Disease: Crohn Disease
Crohn Disease 		0.070 GeneticVariation disease BEFREE Unlike previous variants (in other genes) reported to predispose to inflammatory bowel disease, the association at MYO9B was considerably stronger with ulcerative colitis, although weaker association with Crohn's disease also was observed. 17087940 2006
CUI: C0010346
Disease: Crohn Disease
Crohn Disease 		0.070 GeneticVariation disease LHGDN Unlike previous variants (in other genes) reported to predispose to inflammatory bowel disease, the association at MYO9B was considerably stronger with ulcerative colitis, although weaker association with Crohn's disease also was observed. 17087940 2006
CUI: C0007570
Disease: Celiac Disease
Celiac Disease 		0.600 GeneticVariation disease BEFREE No MYO9B variants or MYO9B haplotypes were found associated with CD, either before or after stratification of the patients for the human leucocyte antigen (HLA)-DQ2-positive risk factor. 17176439 2006
CUI: C0007570
Disease: Celiac Disease
Celiac Disease 		0.600 GeneticVariation disease LHGDN No MYO9B variants or MYO9B haplotypes were found associated with CD, either before or after stratification of the patients for the human leucocyte antigen (HLA)-DQ2-positive risk factor. 17176439 2006
CUI: C0007570
Disease: Celiac Disease
Celiac Disease 		0.600 GeneticVariation disease BEFREE The MYO9B gene rs 2305764 polymorphism is not associated to coeliac disease in coeliac children from Southern Italy. 17267307 2007
CUI: C0007570
Disease: Celiac Disease
Celiac Disease 		0.600 GeneticVariation disease BEFREE Besides the well known involvement of the HLA class II histocompatibility antigen (HLA)-DQ2.5 and -DQ8 heterodimers (encoded by particular combinations of the HLA-DQA1 and -DQB1 gene) in CD and the minor contribution of the CTLA-4 gene, recently the myosin IXB (MYO9B) gene has also been found to be genetically associated. 17438672 2006