Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast 		0.300 Biomarker disease CTD_human Insertional mutagenesis identifies drivers of a novel oncogenic pathway in invasive lobular breast carcinoma. 28650484 2017
CUI: C0027626
Disease: Neoplasm Invasiveness
Neoplasm Invasiveness 		0.300 Biomarker phenotype CTD_human Insertional mutagenesis identifies drivers of a novel oncogenic pathway in invasive lobular breast carcinoma. 28650484 2017
CUI: C0206692
Disease: Carcinoma, Lobular
Carcinoma, Lobular 		0.300 Biomarker disease CTD_human Insertional mutagenesis identifies drivers of a novel oncogenic pathway in invasive lobular breast carcinoma. 28650484 2017
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma 		0.300 Biomarker disease CTD_human Insertional mutagenesis identifies drivers of a novel oncogenic pathway in invasive lobular breast carcinoma. 28650484 2017
CUI: C1257931
Disease: Mammary Neoplasms, Human
Mammary Neoplasms, Human 		0.300 Biomarker disease CTD_human Insertional mutagenesis identifies drivers of a novel oncogenic pathway in invasive lobular breast carcinoma. 28650484 2017
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms 		0.300 Biomarker group CTD_human Insertional mutagenesis identifies drivers of a novel oncogenic pathway in invasive lobular breast carcinoma. 28650484 2017
CUI: C4704874
Disease: Mammary Carcinoma, Human
Mammary Carcinoma, Human 		0.300 Biomarker disease CTD_human Insertional mutagenesis identifies drivers of a novel oncogenic pathway in invasive lobular breast carcinoma. 28650484 2017
CUI: C0007570
Disease: Celiac Disease
Celiac Disease 		0.110 AlteredExpression disease BEFREE In contrast, PPP1R12B isoform C was up-regulated in the celiac disease mucosa (Fold change 1.9, p < 0.001). 26123480 2015
CUI: C0007570
Disease: Celiac Disease
Celiac Disease 		0.110 GeneticVariation disease GWASCAT A possible mechanism behind autoimmune disorders discovered by genome-wide linkage and association analysis in celiac disease. 23936387 2013
CUI: C0007570
Disease: Celiac Disease
Celiac Disease 		0.110 GeneticVariation disease GWASDB A possible mechanism behind autoimmune disorders discovered by genome-wide linkage and association analysis in celiac disease. 23936387 2013
CUI: C0010068
Disease: Coronary heart disease
Coronary heart disease 		0.100 GeneticVariation disease GWASDB RTN4 and FBXL17 Genes are Associated with Coronary Heart Disease in Genome-Wide Association Analysis of Lithuanian Families. 24778558 2013
CUI: C0010068
Disease: Coronary heart disease
Coronary heart disease 		0.100 GeneticVariation disease GWASCAT RTN4 and FBXL17 Genes are Associated with Coronary Heart Disease in Genome-Wide Association Analysis of Lithuanian Families. 24778558 2013
CUI: C0162534
Disease: Prion Diseases
Prion Diseases 		0.100 GeneticVariation group GWASDB Genome-wide association study in multiple human prion diseases suggests genetic risk factors additional to PRNP. 22210626 2012
CUI: C0162701
Disease: Polysomnography
Polysomnography 		0.100 GeneticVariation phenotype GWASDB Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. 23251661 2012
CUI: C0337434
Disease: Estradiol measurement
Estradiol measurement 		0.100 GeneticVariation phenotype GWASCAT Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. 23251661 2012
CUI: C1443016
Disease: Estradiol level result
Estradiol level result 		0.100 GeneticVariation phenotype GWASCAT Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. 23251661 2012
CUI: C0004096
Disease: Asthma
Asthma 		0.100 GeneticVariation disease GWASDB [Genome-wide association study of allergic diseases in Russians of Western Siberia]. 21790008 2011
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma 		0.010 Biomarker disease BEFREE Further evaluation revealed that PEAK1 expression was positively correlated with protein phosphatase 1 regulatory subunit 12B (PPP1R12B) in CRC cell lines and clinical tissues, and this protein was found to suppress activation of the Grb2/PI3K/Akt pathway. 30472186 2019
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis 		0.010 Biomarker phenotype BEFREE Our results provide compelling evidence that the PEAK1-PPP1R12B axis inhibits colorectal tumorigenesis and metastasis through deactivation of the Grb2/PI3K/Akt pathway, which might provide a novel therapeutic strategy for CRC treatment. 30472186 2019
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.010 Biomarker group BEFREE The PEAK1-PPP1R12B axis inhibits tumor growth and metastasis by regulating Grb2/PI3K/Akt signalling in colorectal cancer. 30472186 2019
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis 		0.010 Biomarker phenotype BEFREE Our results provide compelling evidence that the PEAK1-PPP1R12B axis inhibits colorectal tumorigenesis and metastasis through deactivation of the Grb2/PI3K/Akt pathway, which might provide a novel therapeutic strategy for CRC treatment. 30472186 2019
CUI: C4722085
Disease: Malignant neoplasm of colon and/or rectum
Malignant neoplasm of colon and/or rectum 		0.010 Biomarker disease BEFREE The PEAK1-PPP1R12B axis inhibits tumor growth and metastasis by regulating Grb2/PI3K/Akt signalling in colorectal cancer. 30472186 2019