|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Because ATF3 is an adaptive-response gene and is induced by various stromal signals, these findings have significant implications for how the tumor microenvironment might affect cancer development.
|
20930144 |
2010 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Activating transcription factor 3 (ATF3) is a member of the ATF/CREB subfamily of the basic region-leucine zipper family and has been known as a tumor suppressor in human colorectal cancer cells.
|
20581861 |
2010 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
While providing the cell a general means of responding to diverse adverse environment cues, this mechanism confers ATF3 with an ability to promote tumor suppressor functions.
|
16628010 |
2006 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
We now show that the Wnt/β-catenin pathway is indeed activated in ATF3-induced tumors.
|
21304988 |
2011 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
In addition, the role of ATF3 in promoting in vivo tumor growth and hepatic metastasis was investigated by shRNA-mediated knockdown of ATF3.
|
24859834 |
2014 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The prevention of p53 degradation was unlikely caused by binding of ATF3 to the tumor suppressor, but rather was a consequence of disruption of the E6-E6AP interaction by ATF3.
|
20167600 |
2010 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Onconase treatment consistently resulted in up-regulation of IL-24, previously shown to have tumor suppressive activity, as well as ATF3 and IL-6.
|
20137089 |
2010 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Immunohistochemical analysis of patient tumor samples revealed that expression of ATF3 in stromal mononuclear cells, but not cancer epithelial cells, is correlated with worse clinical outcomes and is an independent predictor for breast cancer death.
|
23921126 |
2013 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Both cell proliferation in vitro and tumor growth in vivo were suppressed after ATF-3 knockdown.
|
24133584 |
2013 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
High tumorous ATF3 expression was significantly correlated with positive advanced tumor grade, lymph node metastasis, and shorter overall survival.
|
28239957 |
2017 |
|
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Especially, it caused the induction of growth-related transcriptional regulators (Jun, N-myc, Atf3) and the reduction of Rassf1 and two dehydrogenase genes (Dhrs1 and Adh5), which may be involved in the carcinogenesis of IDH1-mutated tumors.
|
21356389 |
2011 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The impact of ATF3 down-regulation on cancer growth and metastasis were investigated in a subcutaneous tumor model, a model of hepatic tumor growth and in a model of peritoneal carcinomatosis.
|
21129190 |
2010 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Here we employed systems analysis to identify genome-wide targets of ATF3 that is either induced by an alkylating agent methyl methanesulfonate (MMS) or over-expressed in a prostate tumour cell line LNCaP.
|
22046379 |
2011 |