|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Collectively, our results suggest that ATF3 and JDP2 regulate the expression of essential tumor promoting factors expressed by fibroblasts within the tumor microenvironment, and thus restrain tumor growth.
|
30670778 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
However, whether ATF3 contributes to the maintenance of genome stability and tumor suppression remains unknown.
|
28869597 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Our findings indicate that ATF3 functions as a tumor suppressor in HCC through targeting and regulating CYR61.
|
30376856 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Based upon piRNA:mRNA sequence complementarity, we identified a panel of tumor suppressor genes (ATF3, BTG1, DUSP1, FAS,NFKBIA, UPP1, SESN2, TP53INP1 and MDX1) as direct targets of piR-1245, and successfully validated an inverse correlation between their expression and piR-1245 in CRC.
|
29382334 |
2018 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
ARTD treatment induced the expression of tumor suppressive activating transcription factor 3 and inhibited oncogenic E2F transcription factor 1 expression at the mRNA and protein levels.
|
30205376 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Tumour xenograft was used to evaluate the effect of ATF3 in vivo.
|
30117642 |
2018 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Under physiological conditions, ATF3 expression is transient and plays a pivotal role in controlling the expression of cell-cycle regulators and tumor suppressor, DNA repair, and apoptosis genes.
|
30144543 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Expectedly, the analysis of the DEGs common to all three alterations highlighted a group of BioFunctions that included Cell Proliferation of tumor cell lines (14 DEGs), Invasion of cells (10 DEGs) and Migration of tumour cell lines (10 DEGs), with a common core of 5 genes (ATF3, CDKN1A, GDF15, HBEGF and LCN2) that likely represent downstream effectors of the pro-oncogenic activities of PI3K/AKT signalling.
|
28662101 |
2017 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
We further demonstrate that the proapoptotic function of ATF3 is mediated through direct transcriptional repression of the prosurvival factor <i>BCL-X<sub>L</sub> (BCL2L1)</i> These findings provided the rationale for dual inhibition of HDAC and BCL-X<sub>L</sub>, which we show strongly cooperate to overcome inherent resistance to HDACi across diverse tumor cell types.<b>Conclusions:</b> These findings explain the heterogeneous responses of tumor cells to HDACi-induced apoptosis and suggest a framework for predicting response and expanding their therapeutic use in multiple cancer types.<i></i>.
|
28611196 |
2017 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Gene expression analysis in tumor adjacent normal (pre-neoplastic) tissue identified several genes involved in proliferation (Fosb, Fos, Ptk6, Esr2, Atf3) and inflammation (Atf3, Saa1, TNF-α) that were downregulated in MthfdS<sup>+/-</sup> males.
|
27597531 |
2017 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
High tumorous ATF3 expression was significantly correlated with positive advanced tumor grade, lymph node metastasis, and shorter overall survival.
|
28239957 |
2017 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
In vivo, control xenograft tumors were significantly more responsive to treatment than ATF3 knockdown xenografts.
|
27196751 |
2016 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Our results thus support that ATF3 is a tumor suppressor in prostate cancer.
|
26522727 |
2016 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
We conclude that ATF3 can suppress mutp53 oncogenic function, thereby contributing to tumor suppression in TP53-mutated cancer.
|
24554706 |
2014 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
ATF3 functions as a novel tumor suppressor with prognostic significance in esophageal squamous cell carcinoma.
|
25149542 |
2014 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Low expression of ATF3 may function as a tumor suppressor during human hepatocellular oncogenesis and targeting ATF3 pathway might be beneficial for anti-HCC therapy.
|
24906227 |
2014 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
In addition, the role of ATF3 in promoting in vivo tumor growth and hepatic metastasis was investigated by shRNA-mediated knockdown of ATF3.
|
24859834 |
2014 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
We show that Atf3 is a tumor-suppressor gene inactivated in human glioblastoma multiforme together with Cbx7 and a few other candidates.
|
23680149 |
2013 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Together, the results indicate that ATF3 might promote skin cancer cell proliferation and enhance skin keratinocyte tumor development through inhibiting p53 expression and then activating Stat3 phosphorylation.
|
24460316 |
2013 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Immunohistochemical analysis of patient tumor samples revealed that expression of ATF3 in stromal mononuclear cells, but not cancer epithelial cells, is correlated with worse clinical outcomes and is an independent predictor for breast cancer death.
|
23921126 |
2013 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Both cell proliferation in vitro and tumor growth in vivo were suppressed after ATF-3 knockdown.
|
24133584 |
2013 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
TRPV1 stimulation triggers tumor cell death through the branch of the endoplasmic reticulum stress pathway that is controlled by activating transcription factor-3 (ATF3).
|
22820645 |
2012 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
IL1β, IL6 and iNOS transcripts were up-regulated among external cell signaling factors; nine transcription factors (ATF3, C/EBP, c-Fos, Fos-B, JDP2, JunB, c-Maf, NF-κB, TCF4) showed increased expression and 5 (AP-2, CBP, Elk-1, p53, PEA3) were decreased in tumors with high COX-2.
|
21668942 |
2011 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Activating transcription factor 3 (ATF3), a stress response transcription factor, is known to have a dichotomous role in tumor cells, acting either as a tumor suppressor or an oncogene in a context-dependent manner.
|
21900211 |
2011 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
We now show that the Wnt/β-catenin pathway is indeed activated in ATF3-induced tumors.
|
21304988 |
2011 |