ATF3, activating transcription factor 3, 467

N. diseases: 228; N. variants: 4
Disease: Malignant neoplasm of skin ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0007114
Disease: Malignant neoplasm of skin
Malignant neoplasm of skin 		0.040 AlteredExpression disease BEFREE Like CSL, ATF3, a stress-responsive transcriptional repressor, is down-modulated in skin cancer stromal cells, and <i>Atf3</i> knockout mice develop aggressive chemically induced skin tumors with enhanced CAF activation. 28684431 2017
CUI: C0007114
Disease: Malignant neoplasm of skin
Malignant neoplasm of skin 		0.040 Biomarker disease BEFREE Recently, we reported that activating transcription factor 3 (ATF3) could significantly promote skin cancer cell growth. 25371069 2015
CUI: C0007114
Disease: Malignant neoplasm of skin
Malignant neoplasm of skin 		0.040 Biomarker disease BEFREE Together, the results indicate that ATF3 might promote skin cancer cell proliferation and enhance skin keratinocyte tumor development through inhibiting p53 expression and then activating Stat3 phosphorylation. 24460316 2013
CUI: C0007114
Disease: Malignant neoplasm of skin
Malignant neoplasm of skin 		0.040 Biomarker disease BEFREE Opposing roles for calcineurin and ATF3 in squamous skin cancer. 20485437 2010