ATF3, activating transcription factor 3, 467

N. diseases: 228; N. variants: 4
Disease: Colorectal Carcinoma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma 		0.070 AlteredExpression disease BEFREE <b>Conclusion:</b> Increased ATF3 and reduced irisin levels were observed in sera from CRC patients. 30246803 2018
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma 		0.070 Biomarker disease BEFREE Activating transcription factor 3 (ATF3) has been reported to be associated with apoptosis in colorectal cancer. 27871156 2017
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma 		0.070 Biomarker disease BEFREE Critically, in higher ATF3 expression cell lines (HCT116 and RKO) with CRISPR/Cas9 mediated ATF3 knock out, we are able to show that ATF3 target genes such as CEACAM1, DUSP14, HDC, HLF and ULBP2, are required for invasion and proliferation, and they are robustly linked with poor prognosis in CRC. 28402947 2017
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma 		0.070 Biomarker disease BEFREE The present study was undertaken in order to investigate whether ATF3 influences cancer-related phenotypes in colorectal cancer. 26851004 2016
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma 		0.070 Biomarker disease BEFREE Activating transcription factor 3 (ATF3) has been reported to be associated with apoptosis in colorectal cancer. 27043582 2016
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma 		0.070 Biomarker disease BEFREE Activating transcription factor 3 (ATF3) is a member of the ATF/c-AMP response element-binding (CREB) subfamily of the basic-region leucine zipper family and has been known to induce apoptosis in human colorectal cancer (CRC) cells. 22819556 2013
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma 		0.070 AlteredExpression disease BEFREE ATF3 expression was also increased by patulin in other colorectal cancer cell types, Caco2 and SW620. 22230687 2012