ATF3, activating transcription factor 3, 467

N. diseases: 228; N. variants: 4
Disease: Hyperglycemia ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0020456
Disease: Hyperglycemia
Hyperglycemia 		0.030 Biomarker disease BEFREE Interestingly, HFD-fed ATF3-cKO mice display increased hyperglycemia and reduced glucose tolerance, despite higher blood insulin levels, as compared to HFD-fed WT mice. 28082453 2017
CUI: C0020456
Disease: Hyperglycemia
Hyperglycemia 		0.030 Biomarker disease BEFREE PDX-1 was decreased in MIN6N8 cells treated with high glucose or high palmitate, whereas ATF3 was increased, indicating that ATF3 plays a role in hyperglycemia or hyperlipidemia-mediated downregulation of PDX-1 expression. 21821004 2011
CUI: C0020456
Disease: Hyperglycemia
Hyperglycemia 		0.030 AlteredExpression disease BEFREE Importantly, ATF3 expression was increased in hyperglycemia or TNF-α-treated C2C12 cells in which AdipoR1 expression was decreased, suggesting that ATF3 may contribute to downregulation of AdipoR1 by hyperglycemia and TNF-α. 20696134 2010