ATF4, activating transcription factor 4, 468

N. diseases: 169; N. variants: 3
Disease: Fatty Liver ×
Source: BEFREE ×
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0015695
Disease: Fatty Liver
Fatty Liver 		0.330 Biomarker disease BEFREE G0S2 is regulated by the PERK-eIF2α-ATF4 branch of the UPR and mediates ER stress-induced hepatic steatosis. 31271806 2019
CUI: C0015695
Disease: Fatty Liver
Fatty Liver 		0.330 Biomarker disease BEFREE Moreover, AgRP-ATF4 KO mice were resistant to high-fat diet-induced obesity, insulin resistance, and liver steatosis and maintained at a higher body temperature under cold stress. 27993927 2017
CUI: C0015695
Disease: Fatty Liver
Fatty Liver 		0.330 Biomarker disease BEFREE We observed early-onset hyperlipidaemia and liver steatosis in ATF4 transgenic zebrafish (ATs) without doxycycline treatment (ATs - Dox). 29180630 2017