ATF4, activating transcription factor 4, 468

N. diseases: 178; N. variants: 4
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C2711227
Disease: Steatohepatitis
Steatohepatitis 		0.340 AlteredExpression disease BEFREE Interestingly, acylated and desacyl ghrelin inhibited steatosis and inflammation of palmitate-treated hepatocytes in parallel to an upregulation of OXPHOS complexes II, III, and V, and a downregulation of ER stress transducers IRE1α, PERK, ATF6, their downstream effectors, ATF4 and CHOP, as well as chaperone GRP78. 31324878 2020
CUI: C2711227
Disease: Steatohepatitis
Steatohepatitis 		0.340 Biomarker disease BEFREE G0S2 is regulated by the PERK-eIF2α-ATF4 branch of the UPR and mediates ER stress-induced hepatic steatosis. 31271806 2019
CUI: C2711227
Disease: Steatohepatitis
Steatohepatitis 		0.340 Biomarker disease BEFREE Moreover, AgRP-ATF4 KO mice were resistant to high-fat diet-induced obesity, insulin resistance, and liver steatosis and maintained at a higher body temperature under cold stress. 27993927 2017
CUI: C2711227
Disease: Steatohepatitis
Steatohepatitis 		0.340 Biomarker disease BEFREE We observed early-onset hyperlipidaemia and liver steatosis in ATF4 transgenic zebrafish (ATs) without doxycycline treatment (ATs - Dox). 29180630 2017
CUI: C2711227
Disease: Steatohepatitis
Steatohepatitis 		0.340 Biomarker disease CTD_human ED+E induced steatosis in WT mice, which correlated with a marked up-regulation of activating transcription factor 4 protein (ATF4) but down-regulation of C/EBP homologous protein (CHOP) and sterol regulatory element-binding transcription factor 1c protein (SREBP-1c). 27664470 2016
CUI: C0015695
Disease: Fatty Liver
Fatty Liver 		0.330 Biomarker disease BEFREE G0S2 is regulated by the PERK-eIF2α-ATF4 branch of the UPR and mediates ER stress-induced hepatic steatosis. 31271806 2019
CUI: C0015695
Disease: Fatty Liver
Fatty Liver 		0.330 Biomarker disease BEFREE Moreover, AgRP-ATF4 KO mice were resistant to high-fat diet-induced obesity, insulin resistance, and liver steatosis and maintained at a higher body temperature under cold stress. 27993927 2017
CUI: C0015695
Disease: Fatty Liver
Fatty Liver 		0.330 Biomarker disease BEFREE We observed early-onset hyperlipidaemia and liver steatosis in ATF4 transgenic zebrafish (ATs) without doxycycline treatment (ATs - Dox). 29180630 2017
CUI: C0015695
Disease: Fatty Liver
Fatty Liver 		0.330 Biomarker disease CTD_human REV-ERBα Activates C/EBP Homologous Protein to Control Small Heterodimer Partner-Mediated Oscillation of Alcoholic Fatty Liver. 27664470 2016
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.320 GeneticVariation disease BEFREE Specifically, our cell biology and gene expression studies have revealed that DISC1 Leu607Phe variation, which changes DISC1 interaction with activating transcription factor 4 (ATF4), modifies gene expression patterns upon T. gondii infection. 30127472 2020
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.320 Biomarker disease PSYGENET These findings support that ATF4 gene may be involved in susceptibility to schizophrenia with sex-dependent effect in the Chinese Han population and suggest that further functional assays are needed to verify their relevance to the pathogenesis of schizophrenia. 18163433 2008
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.320 Biomarker disease LHGDN These findings support that ATF4 gene may be involved in susceptibility to schizophrenia with sex-dependent effect in the Chinese Han population and suggest that further functional assays are needed to verify their relevance to the pathogenesis of schizophrenia. 18163433 2008
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.320 Biomarker disease BEFREE These findings support that ATF4 gene may be involved in susceptibility to schizophrenia with sex-dependent effect in the Chinese Han population and suggest that further functional assays are needed to verify their relevance to the pathogenesis of schizophrenia. 18163433 2008
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.310 Biomarker disease PSYGENET We carried out an association study of BD with CREB1, CREB2 and CREB3 genes, located at ch 2q32.3-q34, 22q13.1 and 9pter-p22.1, respectively. 18189280 2008
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.310 Biomarker disease BEFREE In this study, we tested genetic association of ATF4 and ATF5 genes with bipolar disorder by a case-control study in Japanese population (438 patients and 532 controls) and transmission disequilibrium test in 237 trio samples from NIMH Genetics Initiative Pedigrees. 17346882 2007
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.310 Biomarker disease PSYGENET In this study, we tested genetic association of ATF4 and ATF5 genes with bipolar disorder by a case-control study in Japanese population (438 patients and 532 controls) and transmission disequilibrium test in 237 trio samples from NIMH Genetics Initiative Pedigrees. 17346882 2007
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.310 GeneticVariation disease LHGDN In this study, we tested genetic association of ATF4 and ATF5 genes with bipolar disorder by a case-control study in Japanese population (438 patients and 532 controls) and transmission disequilibrium test in 237 trio samples from NIMH Genetics Initiative Pedigrees. 17346882 2007
CUI: C0011570
Disease: Mental Depression
Mental Depression 		0.300 Biomarker disease PSYGENET In contrast, ATF3 or ATF4 overexpression in nucleus accumbens decreases emotional reactivity and increases depression-like behavior, consistent with the behavioral phenotype induced by CREB. 18305237 2008
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.300 Biomarker disease PSYGENET In contrast, ATF3 or ATF4 overexpression in nucleus accumbens decreases emotional reactivity and increases depression-like behavior, consistent with the behavioral phenotype induced by CREB. 18305237 2008
CUI: C0003129
Disease: Anoxemia
Anoxemia 		0.300 Biomarker phenotype CTD_human Anoxic induction of ATF-4 through HIF-1-independent pathways of protein stabilization in human cancer cells. 14604972 2004
CUI: C0003130
Disease: Anoxia
Anoxia 		0.300 Biomarker phenotype CTD_human By applying RNAi, ATF-4 induction in anoxia was shown to be independent of HIF-1alpha, and desferrioxamine mesylate (DFO) and cobalt chloride induced HIF-1alpha but not ATF-4 or GADD153. 14604972 2004
CUI: C0021367
Disease: Mammary Ductal Carcinoma
Mammary Ductal Carcinoma 		0.300 Biomarker disease CTD_human Anoxic induction of ATF-4 through HIF-1-independent pathways of protein stabilization in human cancer cells. 14604972 2004
CUI: C0027540
Disease: Necrosis
Necrosis 		0.300 Biomarker phenotype CTD_human Extracts from primary human tumors demonstrated more ATF-4 expression in tumors near necrotic areas. 14604972 2004
CUI: C0242184
Disease: Hypoxia
Hypoxia 		0.300 Biomarker phenotype CTD_human Here we report a differential response of cancer cells to hypoxia and anoxia by demonstrating the induction of activating transcription factor-4 (ATF-4) and growth arrest DNA damage 153 (GADD153) protein specifically in anoxia and the lack of induction in hypoxia. 14604972 2004
CUI: C0700292
Disease: Hypoxemia
Hypoxemia 		0.300 Biomarker phenotype CTD_human Anoxic induction of ATF-4 through HIF-1-independent pathways of protein stabilization in human cancer cells. 14604972 2004