NDN, necdin, MAGE family member, 4692

N. diseases: 124; N. variants: 2
Disease: Prader-Willi Syndrome ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0032897
Disease: Prader-Willi Syndrome
Prader-Willi Syndrome 		0.600 AlteredExpression disease BEFREE Necdin shapes serotonergic development and SERT activity modulating breathing in a mouse model for Prader-Willi syndrome. 29087295 2017
CUI: C0032897
Disease: Prader-Willi Syndrome
Prader-Willi Syndrome 		0.600 Biomarker disease BEFREE Loss of MAGEL2 and necdin may uncouple LepR from ubiquitination pathways, providing a cellular mechanism for obesity in PWS. 28973533 2017
CUI: C0032897
Disease: Prader-Willi Syndrome
Prader-Willi Syndrome 		0.600 Biomarker disease BEFREE This can help clarify NDN's role in the PWS phenotype. 28213671 2017
CUI: C0032897
Disease: Prader-Willi Syndrome
Prader-Willi Syndrome 		0.600 Biomarker disease BEFREE Methylation-specific multiplex ligation-dependant probe amplification (MS-MLPA) analysis showed hypermethylation of the SNRPN and NDN genes in the PWS/AS critical region of chromosome 15 in this patient. 24704109 2015
CUI: C0032897
Disease: Prader-Willi Syndrome
Prader-Willi Syndrome 		0.600 Biomarker disease BEFREE The gene for necdin, a MAGE-D1-binding protein, has been described as responsible for Prader-Willi syndrome. 23314527 2013
CUI: C0032897
Disease: Prader-Willi Syndrome
Prader-Willi Syndrome 		0.600 Biomarker disease BEFREE Prader-Willi Syndrome (PWS) is a neurodevelopmental disease involving imprinted genes, including NDN, which are only expressed from the paternally inherited allele, with the maternally inherited allele silent. 24039599 2013
CUI: C0032897
Disease: Prader-Willi Syndrome
Prader-Willi Syndrome 		0.600 Biomarker disease BEFREE Necdin is one of several genes inactivated in children with Prader-Willi syndrome, who are predisposed to increased adiposity at the expense of lean mass. 22305984 2012
CUI: C0032897
Disease: Prader-Willi Syndrome
Prader-Willi Syndrome 		0.600 GeneticVariation disease BEFREE Necdin deletion is associated with Prader-Willi syndrome. 21150695 2011
CUI: C0032897
Disease: Prader-Willi Syndrome
Prader-Willi Syndrome 		0.600 Biomarker disease BEFREE Necdin-deficient mice develop symptoms of PWS, including a sensory and motor deficit. 21912643 2011
CUI: C0032897
Disease: Prader-Willi Syndrome
Prader-Willi Syndrome 		0.600 Biomarker disease BEFREE In humans, necdin plays a potential role in the hypogonadotropic hypogonadism phenotype in patients with Prader-Willi syndrome. 21543378 2011
CUI: C0032897
Disease: Prader-Willi Syndrome
Prader-Willi Syndrome 		0.600 Biomarker disease BEFREE NDN is one of several genes inactivated in Prader-Willi syndrome (PWS), a developmental disorder characterized by obesity, hypotonia, and developmental delay. 20665884 2010
CUI: C0032897
Disease: Prader-Willi Syndrome
Prader-Willi Syndrome 		0.600 Biomarker disease BEFREE Together, these results indicate that lack of necdin during development likely contributes to the hypogonadotrophic hypogonadal phenotype in individuals with PWS. 18930956 2009
CUI: C0032897
Disease: Prader-Willi Syndrome
Prader-Willi Syndrome 		0.600 Biomarker disease BEFREE We conclude that a deficiency of MKRN3, MAGEL2 and NDN is not sufficient to cause PWS. 19066619 2009
CUI: C0032897
Disease: Prader-Willi Syndrome
Prader-Willi Syndrome 		0.600 Biomarker disease BEFREE In Necdin deficient mice, respiratory defects resembling PWS have been shown in vivo and in vitro. 19712904 2009
CUI: C0032897
Disease: Prader-Willi Syndrome
Prader-Willi Syndrome 		0.600 Biomarker disease BEFREE It is caused by the absence of expression of the active paternal genes such as the SNRPN, NDN, and possibly others in the PWS critical region on 15q11-13. 19421899 2009
CUI: C0032897
Disease: Prader-Willi Syndrome
Prader-Willi Syndrome 		0.600 Biomarker disease BEFREE This imprinted region is implicated in the pathogenesis of Prader-Willi syndrome (PWS), a neurodevelopmental disorder, where NDN is one of multiple genes silenced by deletion, maternal uniparental disomy or translocation. 19626646 2009
CUI: C0032897
Disease: Prader-Willi Syndrome
Prader-Willi Syndrome 		0.600 Biomarker disease BEFREE We report first that Necdin-deficiency in mice induces central respiratory deficits reminiscent of Prader-Willi syndrome (irregular rhythm, frequent apneas, and blunted respiratory regulations), second that Necdin is expressed by medullary serotonergic neurons, and third that Necdin deficiency alters the serotonergic metabolism, the morphology of serotonin vesicles in medullary serotonergic neurons but not the number of these cells. 18272695 2008
CUI: C0032897
Disease: Prader-Willi Syndrome
Prader-Willi Syndrome 		0.600 Biomarker disease BEFREE The Prader-Willi syndrome protein necdin interacts with the E1A-like inhibitor of differentiation EID-1 and promotes myoblast differentiation. 18557765 2008
CUI: C0032897
Disease: Prader-Willi Syndrome
Prader-Willi Syndrome 		0.600 Biomarker disease MGD Previously we reported a mouse Necdin knock-out model with similar defects to PWS patients. 17116257 2006
CUI: C0032897
Disease: Prader-Willi Syndrome
Prader-Willi Syndrome 		0.600 Biomarker disease BEFREE We further suggest that loss of necdin contributes to the neurological phenotype of PWS, and raise the possibility that co-deletion of necdin and the related protein Magel2 may explain the lack of single gene mutations in PWS. 15649943 2005
CUI: C0032897
Disease: Prader-Willi Syndrome
Prader-Willi Syndrome 		0.600 Biomarker disease BEFREE However, we demonstrate that the IC, if required for imprinted regulation, is not involved in the spatio-temporal regulation of distantly located retrotransposed genes such as the Ndn gene in the PWS domain. 15634360 2005
CUI: C0032897
Disease: Prader-Willi Syndrome
Prader-Willi Syndrome 		0.600 Biomarker disease MGD The human necdin gene in chromosome 15q11-q12 is maternally imprinted, paternally transcribed, and not expressed in Prader-Willi syndrome, a human genomic imprinting-associated neurodevelopmental disorder. 16049186 2005
CUI: C0032897
Disease: Prader-Willi Syndrome
Prader-Willi Syndrome 		0.600 Biomarker disease BEFREE Four protein-encoding genes (MKRN3, MAGEL2, NDN and SNURF-SNRPN) and several small nucleolar (sno) RNA genes (HBII-13, HBII-436, HBII-85, HBII-438A, HBII-438B and HBII-52) are expressed from the paternal chromosome only but their contribution to PWS is unclear. 15565282 2005
CUI: C0032897
Disease: Prader-Willi Syndrome
Prader-Willi Syndrome 		0.600 Biomarker disease MGD We propose that necdin deficiency may contribute to observed respiratory abnormalities in individuals with Prader-Willi syndrome through a similar suppression of central respiratory drive. 12629158 2003
CUI: C0032897
Disease: Prader-Willi Syndrome
Prader-Willi Syndrome 		0.600 Biomarker disease BEFREE Necdin acts as a cell cycle regulatory protein and plays a key role in the pathogenesis of Prader-Willi syndrome, a neurogenetic disorder. 11891783 2002