|
Chronic Lymphocytic Leukemia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Although the tumor-suppressor gene ATM in the consensus deletion region was found to be biallelically inactivated in about one third of B-CLL cases, in the majority of those who have this deletion, inactivation of the remaining ATM allele was not observed.
|
15543602 |
2005 |
|
Chronic Lymphocytic Leukemia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
The putative tumor suppressor genes have remained unrevealed until recently, when the ATM gene was found to carry mutations in cases with deletion in B-CLL, MCL and T-PLL.
|
11426547 |
2001 |
|
Chronic Lymphocytic Leukemia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
These data provide the first evidence for the existence of a putative "hepitype" in the ATM gene associated with CLL risk.
|
21910157 |
2011 |
|
Chronic Lymphocytic Leukemia
|
0.700 |
Biomarker
|
disease |
BEFREE |
We have obtained quantitative measurements of radiation-induced apoptosis and radiation-induced ATM autophosphorylation in purified CLL cells from 158 and 140 patients, respectively, and have used multivariate analysis to identify independent contributions of various biological variables on genomic complexity in CLL.
|
20086003 |
2010 |
|
Chronic Lymphocytic Leukemia
|
0.700 |
Biomarker
|
disease |
BEFREE |
This study sought to establish whether functional analysis of the ATM-p53-p21 pathway adds to the information provided by currently available prognostic factors in patients with chronic lymphocytic leukemia (CLL) requiring frontline chemotherapy.
|
22675167 |
2012 |
|
Chronic Lymphocytic Leukemia
|
0.700 |
Biomarker
|
disease |
BEFREE |
We investigated in vitro sensitivity to the poly (ADP-ribose) polymerase inhibitor olaparib (AZD2281) of 5 ATM mutant lymphoblastoid cell lines (LCL), an ATM mutant MCL cell line, an ATM knockdown PGA CLL cell line, and 9 ATM-deficient primary CLLs induced to cycle and observed differential killing compared with ATM wildtype counterparts.
|
20739657 |
2010 |
|
Chronic Lymphocytic Leukemia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
ATM mutation rather than BIRC3 deletion and/or mutation predicts reduced survival in 11q-deleted chronic lymphocytic leukemia: data from the UK LRF CLL4 trial.
|
24584352 |
2014 |
|
Chronic Lymphocytic Leukemia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
At the clinically relevant concentration of fludarabine, TP53-abnormal samples exhibited markedly higher resistance to fludarabine than the remaining CLL samples (P = 0.012); cohort with ATM deletion was not more resistant than wt cells.
|
19018867 |
2009 |
|
Chronic Lymphocytic Leukemia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Nonetheless, non-mutated IgV(H) gene rearrangement, ATM (11q22-23) and p53 (17p13) deletion are recognized as unfavorable prognosticators in chronic lymphocytic leukemia.
|
19898425 |
2010 |
|
Chronic Lymphocytic Leukemia
|
0.700 |
Biomarker
|
disease |
BEFREE |
These results indicate an association between BLA and reduced expression of ATM, suggesting a role for ATM in disease progression in B-CLL.
|
17213020 |
2007 |
|
Chronic Lymphocytic Leukemia
|
0.700 |
Biomarker
|
disease |
BEFREE |
Recurrent losses or gains of genomic material as well as mutations of key tumor suppressors (ATM and TP53) have been identified in chronic lymphocytic leukemia (CLL).
|
21435757 |
2011 |
|
Chronic Lymphocytic Leukemia
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
Incubation of CLL-exosomes, derived either from cell culture supernatants or from patient plasma, with human stromal cells shows that they are readily taken up into endosomes, and induce expression of genes such as c-fos and ATM as well as enhance proliferation of recipient HS-5 cells.
|
26509439 |
2015 |
|
Chronic Lymphocytic Leukemia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Deletions in ATM gene region have been found in B-cell chronic lymphocytic leukemia (B-CLL) and mantle cell lymphoma (MCL) and have been considered as an independent prognosis factor in these pathologies.
|
14607769 |
2003 |
|
Chronic Lymphocytic Leukemia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
In a subtype-specific analysis, associations were also observed for the ATM locus among both diffuse large B-cell lymphomas (DLBCL) and small lymphocytic lymphomas (SLL), however there was no association observed among follicular lymphomas (FL).
|
25010664 |
2014 |
|
Chronic Lymphocytic Leukemia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Our findings implicate variants in the ATM-BRCA2-CHEK2 DNA damage-response axis with risk of CLL.
|
16574953 |
2006 |
|
Chronic Lymphocytic Leukemia
|
0.700 |
Biomarker
|
disease |
BEFREE |
We show that the ATM gene is mutated in a fraction of B-CLLs and that mutations can be present in the germ line of patients, suggesting that ATM heterozygotes may be predisposed to B-CLL.
|
9892178 |
1999 |
|
Chronic Lymphocytic Leukemia
|
0.700 |
GeneticVariation
|
disease |
UNIPROT |
|
|
|
|
Chronic Lymphocytic Leukemia
|
0.700 |
Biomarker
|
disease |
BEFREE |
Here, we summarize the present knowledge of CLL metabolism, as well as the metabolic influence of Myc, ATM and p53 on CLL lymphocytes.
|
30771875 |
2019 |
|
Chronic Lymphocytic Leukemia
|
0.700 |
Biomarker
|
disease |
BEFREE |
Considering the aberrations in the ATM gene in CLL and the high rate of incidence of lymphoid neoplasias in AT patients, the authors investigated its incidence rate and significance in patients with adult acute lymphoblastic leukemia (ALL).
|
10699895 |
2000 |
|
Chronic Lymphocytic Leukemia
|
0.700 |
SomaticCausalMutation
|
disease |
ORPHANET |
In five B-CLLs and one MCL with deletion of one ATM allele, a point mutation in the remaining allele was detected, which resulted in aberrant transcript splicing, alteration, or truncation of the protein.
|
10397742 |
1999 |
|
Chronic Lymphocytic Leukemia
|
0.700 |
Biomarker
|
disease |
BEFREE |
Mutations in telomere-maintenance pathway genes POT1 and ATM were more frequent in UR-CLL compared to UN-CLL and W-CLL (both p < 0.05).
|
29720177 |
2018 |
|
Chronic Lymphocytic Leukemia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
The MEC-1 and GRANTA-519 cells can be especially recommended for in vivo study of p53-mutated chronic lymphocytic leukemia and ATM-mutated mantle cell lymphoma, respectively.
|
25827173 |
2015 |
|
Chronic Lymphocytic Leukemia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Combined imaging/ fluorescence-in-situ hybridization performed in four SM-AHNMD cases revealed shared abnormal signals in mast cells and myeloid cells in two patients with SM-CMML and one patient with SM-MDS, but not in the mast cells of a case SM-associated with chronic lymphocytic leukemia with ATM-deletion.
|
23440662 |
2013 |
|
Chronic Lymphocytic Leukemia
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
Based on this, we propose that one molecular mechanism by which 11q23 deletions confer a poor prognosis in CLL is via increased TfR expression secondary to ATM loss, resulting in the increased cellular iron import, and hence increased capacity for malignant growth.
|
16326028 |
2006 |
|
Chronic Lymphocytic Leukemia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
There are genomic aberrations detected in over 80% of CLL cases, and genes potentially involved in the pathogenesis were identified with ATM in a subset of cases with 11q deletion and p53 in cases with 17p13 deletion.
|
15325701 |
2004 |