Chronic Lymphocytic Leukemia
|
0.700 |
GeneticVariation
|
disease |
UNIPROT |
|
|
|
Chronic Lymphocytic Leukemia
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
An additional 111 cases of B-CLL were studied for expression of ATM protein by Western blot analysis and RIA.
|
9788599 |
1998 |
Chronic Lymphocytic Leukemia
|
0.700 |
Biomarker
|
disease |
BEFREE |
We show that the ATM gene is mutated in a fraction of B-CLLs and that mutations can be present in the germ line of patients, suggesting that ATM heterozygotes may be predisposed to B-CLL.
|
9892178 |
1999 |
Chronic Lymphocytic Leukemia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
We have looked for mutations in the ATM gene in sporadic cases of B-cell chronic lymphocytic leukaemia (B-CLL).
|
10023947 |
1999 |
Chronic Lymphocytic Leukemia
|
0.700 |
Biomarker
|
disease |
BEFREE |
Del (17(p13) (involving the p53 tumor-suppressor gene) and del (11)(q22-23) (involving the ataxia-telangiectasia gene [ATM]) seem to be independent prognostic factors for poor survival in chronic lymphocytic leukemia (CLL) patients.
|
10319386 |
1999 |
Chronic Lymphocytic Leukemia
|
0.700 |
SomaticCausalMutation
|
disease |
ORPHANET |
In five B-CLLs and one MCL with deletion of one ATM allele, a point mutation in the remaining allele was detected, which resulted in aberrant transcript splicing, alteration, or truncation of the protein.
|
10397742 |
1999 |
Chronic Lymphocytic Leukemia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
To investigate a potential pathogenic role of ATM in B-cell tumorigenesis, we performed mutation analysis of ATM in 29 malignant lymphomas of B-cell origin (B-CLL = 27; mantle cell lymphoma, [MCL] = 2).
|
10397742 |
1999 |
Chronic Lymphocytic Leukemia
|
0.700 |
Biomarker
|
disease |
BEFREE |
This would imply that ATM is unlikely to make a significant contribution to the three-fold increase in risk of CLL seen in relatives of patients.
|
10516748 |
1999 |
Chronic Lymphocytic Leukemia
|
0.700 |
Biomarker
|
disease |
BEFREE |
Considering the aberrations in the ATM gene in CLL and the high rate of incidence of lymphoid neoplasias in AT patients, the authors investigated its incidence rate and significance in patients with adult acute lymphoblastic leukemia (ALL).
|
10699895 |
2000 |
Chronic Lymphocytic Leukemia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
ATM mutations are also involved in the development of sporadic human cancers such as T-cell prolymphocytic leukemia and B-cell chronic lymphocytic leukemia.
|
10738255 |
2000 |
Chronic Lymphocytic Leukemia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
The putative tumor suppressor genes have remained unrevealed until recently, when the ATM gene was found to carry mutations in cases with deletion in B-CLL, MCL and T-PLL.
|
11426547 |
2001 |
Chronic Lymphocytic Leukemia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Frequent inactivating mutations of the ATM gene have been reported in patients with rare sporadic T cell prolymphocytic leukaemia (T-PLL), B cell chronic lymphocytic leukaemia (B-CLL), and most recently, mantle cell lymphoma (MCL).
|
11429421 |
2001 |
Chronic Lymphocytic Leukemia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Here, we show that p53 dysfunction in B-cell chronic lymphocytic leukemia (CLL) can occur in the absence of TP53 mutation and that such dysfunction is associated with mutation of the gene encoding ATM, a kinase implicated in p53 activation.
|
11468183 |
2001 |
Chronic Lymphocytic Leukemia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Here the role of ATM mutations in the pathogenesis of B-CLL is addressed.
|
11756185 |
2002 |
Chronic Lymphocytic Leukemia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
To examine this proposition further we have screened the ATM gene for mutations in CLLs from 61 individuals in 29 families.
|
12091354 |
2002 |
Chronic Lymphocytic Leukemia
|
0.700 |
GeneticVariation
|
disease |
LHGDN |
To examine this proposition further we have screened the ATM gene for mutations in CLLs from 61 individuals in 29 families.
|
12091354 |
2002 |
Chronic Lymphocytic Leukemia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
While ATM mutations in mature B cell tumours (B-CLL and MCL) represent a mixture of missense and truncating errors distributed across the whole of the ATM coding sequence, mutations in sporadic T-PLL appear to be predominantly missense, clustering in the region encoding the PI-3 kinase catalytic domain of the protein.
|
12400598 |
2002 |
Chronic Lymphocytic Leukemia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Consequently, the greater severity of the TP53-mutant B-CLLs compared with ATM-mutant B-CLLs is consistent with the additive effect of defective apoptotic and elevated survival responses after DNA damage in these tumors.
|
12958068 |
2004 |
Chronic Lymphocytic Leukemia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Deletions in ATM gene region have been found in B-cell chronic lymphocytic leukemia (B-CLL) and mantle cell lymphoma (MCL) and have been considered as an independent prognosis factor in these pathologies.
|
14607769 |
2003 |
Chronic Lymphocytic Leukemia
|
0.700 |
Biomarker
|
disease |
LHGDN |
ATM mutations in B-cell chronic lymphocytic leukemia.
|
14754616 |
2004 |
Chronic Lymphocytic Leukemia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Cryptic deletion involving the ATM locus at 11q22.3 approximately q23.1 in B-cell chronic lymphocytic leukemia and related disorders.
|
15193446 |
2004 |
Chronic Lymphocytic Leukemia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
There are genomic aberrations detected in over 80% of CLL cases, and genes potentially involved in the pathogenesis were identified with ATM in a subset of cases with 11q deletion and p53 in cases with 17p13 deletion.
|
15325701 |
2004 |
Chronic Lymphocytic Leukemia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Although the tumor-suppressor gene ATM in the consensus deletion region was found to be biallelically inactivated in about one third of B-CLL cases, in the majority of those who have this deletion, inactivation of the remaining ATM allele was not observed.
|
15543602 |
2005 |
Chronic Lymphocytic Leukemia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
B-cell chronic lymphocytic leukemia (B-CLL) is a clinically variable disease where mutations in DNA damage response genes ATM or TP53 affect the response to standard therapeutic agents.
|
15692065 |
2005 |
Chronic Lymphocytic Leukemia
|
0.700 |
Biomarker
|
disease |
BEFREE |
Current data indicate that the transformation of chronic lymphocytic leukemia to a large-cell or immunoblastic lymphoma is associated with abnormalities in cell cycle regulation (e.g., loss of the cell cycle inhibitors p16(INK4a) and p27(KIP1) ) and DNA repair (e.g., mutations and/or deletions of the p53, ATM, and p14(ARF) genes and epigenetic silencing of the MLH1 gene).
|
16053658 |
2005 |