NEDD4, NEDD4 E3 ubiquitin protein ligase, 4734

N. diseases: 101; N. variants: 8
Disease: Glioma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0017638
Disease: Glioma
Glioma 		0.040 AlteredExpression disease BEFREE We found that curcumin reduced the expression of NEDD4 and Notch1 and pAKT, leading to glioma cell growth inhibition, apoptosis, and suppression of migration and invasion. 28627598 2017
CUI: C0017638
Disease: Glioma
Glioma 		0.040 Biomarker disease BEFREE In brief, our findings demonstrated the important role of Nedd4-1 in regulating the migration and invasion of glioma cells via the Nedd4-1/Rap2a pathway, which may qualify Nedd4-1 as a viable therapeutic target for glioma. 28405688 2017
CUI: C0017638
Disease: Glioma
Glioma 		0.040 Biomarker disease BEFREE NEDD4‑1 promotes the migration and invasion of glioma cells via the ubiquitination and subsequent degradation of cyclic nucleotide‑Ras guanine nucleotide exchange factors (CNrasGEFs). 26458406 2015
CUI: C0017638
Disease: Glioma
Glioma 		0.040 Biomarker disease BEFREE NEDD4-1 regulates migration and invasion of glioma cells through CNrasGEF ubiquitination in vitro. 24340059 2013