Medulloblastoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
This Atoh1-CS-primary cilium-SHH pro-proliferative pathway is also conserved in SHH-type medulloblastoma, a pediatric brain tumor arising from the GNPs.
|
30695697 |
2019 |
Medulloblastoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Furthermore, we identified Atoh1 as a target and molecular accomplice of Gli2 that activates core SHH MB signature genes in a synergistic manner.
|
30554998 |
2019 |
Medulloblastoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
We discovered tyrosine 78 of Atoh1 is phosphorylated by a Jak2-mediated pathway only in tumor-initiating cells and in human SHH-type medulloblastoma.
|
29168692 |
2017 |
Medulloblastoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Our work reveals a dynamic ATOH1-driven molecular cascade underlying medulloblastoma metastasis that offers possible therapeutic opportunities.<i></i>.
|
28490517 |
2017 |
Medulloblastoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Hence, the crosstalk between SHH signaling and Atoh1 during cerebellar development highlights a collaborative network that could be further targeted in medulloblastoma.
|
24960692 |
2014 |
Medulloblastoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
We found that the transcription factor NEUROG1 (but not ATOH1) is expressed in cLPN, unlike normal adult cerebellum, and that fatty acid binding protein 4 (FABP4), typically found in adipocytes, is significantly overexpressed compared with both normal adult cerebellum and human MB.
|
22476608 |
2012 |
Medulloblastoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Therefore, by targeting multiple genes regulating the differentiation state of GNPs, Atoh1 collaborates with the pro-proliferative Gli1-dependent transcriptional program to influence medulloblastoma development.
|
20516124 |
2010 |
Medulloblastoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Recently, we showed that HIC1 is a direct transcriptional repressor of ATOH1, a proneural transcription factor required for normal cerebellar development, as well as for medulloblastoma cell viability.
|
18974104 |
2008 |
Medulloblastoma
|
0.400 |
Biomarker
|
disease |
CTD_human |
Given that Atoh1 is also a putative target of Hh signaling, we conclude that the Hic1 and Ptch1 tumor suppressors cooperate to silence Atoh1 expression during a critical phase in GCP differentiation in which malignant transformation may lead to medulloblastoma.
|
18347096 |
2008 |
Medulloblastoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Given that Atoh1 is also a putative target of Hh signaling, we conclude that the Hic1 and Ptch1 tumor suppressors cooperate to silence Atoh1 expression during a critical phase in GCP differentiation in which malignant transformation may lead to medulloblastoma.
|
18347096 |
2008 |
Medulloblastoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
GLI1 transcript was expressed in medulloblastomas with ATOH1 transcript, whereas high levels of MYC transcript were unrelated to NEUROG1 or ATOH1 expression.
|
17522332 |
2007 |
Childhood Medulloblastoma
|
0.390 |
Biomarker
|
disease |
BEFREE |
This Atoh1-CS-primary cilium-SHH pro-proliferative pathway is also conserved in SHH-type medulloblastoma, a pediatric brain tumor arising from the GNPs.
|
30695697 |
2019 |
Childhood Medulloblastoma
|
0.390 |
Biomarker
|
disease |
BEFREE |
Furthermore, we identified Atoh1 as a target and molecular accomplice of Gli2 that activates core SHH MB signature genes in a synergistic manner.
|
30554998 |
2019 |
Adult Medulloblastoma
|
0.390 |
Biomarker
|
disease |
BEFREE |
Furthermore, we identified Atoh1 as a target and molecular accomplice of Gli2 that activates core SHH MB signature genes in a synergistic manner.
|
30554998 |
2019 |
Adult Medulloblastoma
|
0.390 |
Biomarker
|
disease |
BEFREE |
This Atoh1-CS-primary cilium-SHH pro-proliferative pathway is also conserved in SHH-type medulloblastoma, a pediatric brain tumor arising from the GNPs.
|
30695697 |
2019 |
Childhood Medulloblastoma
|
0.390 |
Biomarker
|
disease |
BEFREE |
Our work reveals a dynamic ATOH1-driven molecular cascade underlying medulloblastoma metastasis that offers possible therapeutic opportunities.<i></i>.
|
28490517 |
2017 |
Childhood Medulloblastoma
|
0.390 |
Biomarker
|
disease |
BEFREE |
We discovered tyrosine 78 of Atoh1 is phosphorylated by a Jak2-mediated pathway only in tumor-initiating cells and in human SHH-type medulloblastoma.
|
29168692 |
2017 |
Adult Medulloblastoma
|
0.390 |
Biomarker
|
disease |
BEFREE |
We discovered tyrosine 78 of Atoh1 is phosphorylated by a Jak2-mediated pathway only in tumor-initiating cells and in human SHH-type medulloblastoma.
|
29168692 |
2017 |
Adult Medulloblastoma
|
0.390 |
Biomarker
|
disease |
BEFREE |
Our work reveals a dynamic ATOH1-driven molecular cascade underlying medulloblastoma metastasis that offers possible therapeutic opportunities.<i></i>.
|
28490517 |
2017 |
Childhood Medulloblastoma
|
0.390 |
Biomarker
|
disease |
BEFREE |
Hence, the crosstalk between SHH signaling and Atoh1 during cerebellar development highlights a collaborative network that could be further targeted in medulloblastoma.
|
24960692 |
2014 |
Adult Medulloblastoma
|
0.390 |
Biomarker
|
disease |
BEFREE |
Hence, the crosstalk between SHH signaling and Atoh1 during cerebellar development highlights a collaborative network that could be further targeted in medulloblastoma.
|
24960692 |
2014 |
Childhood Medulloblastoma
|
0.390 |
AlteredExpression
|
disease |
BEFREE |
We found that the transcription factor NEUROG1 (but not ATOH1) is expressed in cLPN, unlike normal adult cerebellum, and that fatty acid binding protein 4 (FABP4), typically found in adipocytes, is significantly overexpressed compared with both normal adult cerebellum and human MB.
|
22476608 |
2012 |
Adult Medulloblastoma
|
0.390 |
AlteredExpression
|
disease |
BEFREE |
We found that the transcription factor NEUROG1 (but not ATOH1) is expressed in cLPN, unlike normal adult cerebellum, and that fatty acid binding protein 4 (FABP4), typically found in adipocytes, is significantly overexpressed compared with both normal adult cerebellum and human MB.
|
22476608 |
2012 |
Childhood Medulloblastoma
|
0.390 |
Biomarker
|
disease |
BEFREE |
Therefore, by targeting multiple genes regulating the differentiation state of GNPs, Atoh1 collaborates with the pro-proliferative Gli1-dependent transcriptional program to influence medulloblastoma development.
|
20516124 |
2010 |
Adult Medulloblastoma
|
0.390 |
Biomarker
|
disease |
BEFREE |
Therefore, by targeting multiple genes regulating the differentiation state of GNPs, Atoh1 collaborates with the pro-proliferative Gli1-dependent transcriptional program to influence medulloblastoma development.
|
20516124 |
2010 |