NEFL, neurofilament light, 4747

N. diseases: 247; N. variants: 26
Disease: Prion Diseases ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0162534
Disease: Prion Diseases
Prion Diseases 		0.030 Biomarker group BEFREE Increased CSF Neurofilament light chain (NFL) concentrations have been reported in several neurological disorders, including prion diseases. 30309804 2019
CUI: C0162534
Disease: Prion Diseases
Prion Diseases 		0.030 Biomarker group BEFREE The very rapid neurodegeneration of prion disease results in strong signals from surrogate protein markers in the blood that reflect neuronal, axonal, synaptic or glial pathology in the brain: notably the tau and neurofilament light chain proteins. 30529227 2019
CUI: C0162534
Disease: Prion Diseases
Prion Diseases 		0.030 GeneticVariation group BEFREE Compared to nonprimarily neurodegenerative neurological and psychiatric diseases, NFL was also elevated in genetic prion diseases associated with the E200K, V210I, P102L, and D178N prion protein gene mutations. 29391125 2018