NEFL, neurofilament light, 4747

N. diseases: 247; N. variants: 26
Disease: Mental deterioration ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0234985
Disease: Mental deterioration
Mental deterioration 		0.040 Biomarker phenotype BEFREE We demonstrated that plasma Aβ40, Aβ42, t-tau, and NFL may be useful to identify aMCI and correlate with cognitive decline and brain atrophy. 31145586 2019
CUI: C0234985
Disease: Mental deterioration
Mental deterioration 		0.040 Biomarker phenotype BEFREE Elevated baseline plasma NfL is a prognostic marker of cognitive decline and neuroimaging measures of neurodegeneration, and has similar effect sizes to baseline CSF NfL. 31182505 2019
CUI: C0234985
Disease: Mental deterioration
Mental deterioration 		0.040 Biomarker phenotype BEFREE Plasma NFL may represent a biomarker of cognitive decline in AD and PD, with more specificity for AD. 30478269 2018
CUI: C0234985
Disease: Mental deterioration
Mental deterioration 		0.040 AlteredExpression phenotype BEFREE For all diagnostic groups, higher CSF NfL levels were associated with faster frontal cognitive decline. 30103065 2018