Neuroblastoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Multifocal primary neuroblastoma tumor heterogeneity in siblings with co-occurring PHOX2B and NF1 genetic aberrations.
|
31515834 |
2020 |
Neuroblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
As neurofibromin activity is a key to regulating the RAS/MAPK pathway, NF1 mutations are important in the acquisition of drug resistance, to BRAF, EGFR inhibitors, tamoxifen and retinoic acid in melanoma, lung and breast cancers and neuroblastoma.
|
28637487 |
2017 |
Neuroblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
NF1 protein levels in neuroblastoma cell lines were determined using Western blot assays.
|
26925841 |
2016 |
Neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
To this end, short-term parallel cultures of SK-NF-I neuroblastoma cells were treated with TSA either alone or in combination with hypoxia, and mRNA levels of dopamine receptor D3 (DRD3) and D4 (DRD4), dopamine transporter (DAT), dopamine hydroxylase (DBH), dopamine receptor regulating factor (DRRF), catechol-O-methyltransferase (COMT), serotonin receptor 1A (HTR1A), monoamino oxidase A (MAO-A), serotonin transporter (SLC6A4) and tryptophan hydroxylase 2 (TPH2) were determined by quantitative PCR.
|
21785940 |
2012 |
Neuroblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
12-O-tetradecanoyl-phorbol-13-acetate-dependent up-regulation of dopaminergic gene expression requires Ras and neurofibromin in human IMR-32 neuroblastoma.
|
16635257 |
2006 |
Neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Lysates from Drosophila S2 cells expressing exogenous Sp1, Sp3, and NF-1 proteins were able to partially mimic gel shift complexes seen with neuroblastoma nuclear extract and either wild type or mutant probes.
|
14567977 |
2004 |
Neuroblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In pPNET cells levels of type 1 GAP120 but not neurofibromin mRNA were increased to similar levels to those in neuroblastoma cells.
|
9619634 |
1998 |
Neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Recent publications have indicated that the NF1 gene can be rearranged in neuroblastoma cell lines.
|
9169039 |
1997 |
Neuroblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Loss of NF1 gene expression has been reported in Schwann cell tumors (neurofibrosarcomas) from patients with NF1 as well as in malignant melanomas and neuroblastomas from patients without NF1.
|
7542904 |
1995 |
Neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
However, the GTPase activating proteins type I GAP120 and neurofibromin may have effector functions in RA-induced differentiation of neuroblastoma.
|
7576949 |
1995 |
Neuroblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Here we report that 4 out of 10 human neuroblastoma lines express little or no neurofibromin and that two of these lines show evidence of NF1 mutations, providing further proof that NF1 mutations occur in tumours that are not commonly found in NF1 patients.
|
8490657 |
1993 |
Neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
In contrast to the schwannoma cell lines, GTP-Ras was appropriately regulated in the melanoma and neuroblastoma lines that were deficient in neurofibromin, even when c-H-ras was overexpressed in the lines.
|
8516298 |
1993 |