Meningioma
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
Loss-of-function mutations or deletion of the NF2 gene, resulting in loss of the encoded Merlin protein, lead to Neurofibromatosis type 2 (NF2), but also cause the formation of sporadic meningiomas.
|
31715329 |
2020 |
Meningioma
|
0.800 |
Biomarker
|
disease |
BEFREE |
Next-generation sequencing studies and increasingly sophisticated <i>NF2</i>-deletion-based <i>in vitro</i> and <i>in vivo</i> models have helped elucidate the consequences of merlin loss in meningioma pathogenesis.
|
31652973 |
2019 |
Meningioma
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
To investigate neurofibromatosis type 2 (NF2) gene mutation at mRNA levels in sporadic orbitocranial meningioma and its association with progesterone receptor (PR) mRNA expression.
|
31024808 |
2019 |
Meningioma
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
The most frequent mutation among all meningioma grades occurred in the NF2 gene at 85% (11/13).
|
29846894 |
2018 |
Meningioma
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
The best defined of these syndromes is neurofibromatosis type 2, which is caused by a mutation in the NF2 gene and has a meningioma incidence of approximately 50%.
|
29660026 |
2018 |
Meningioma
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
This revealed that a frameshift deletion of the neurofibromin 2 gene likely drove formation of the meningioma.
|
29764516 |
2018 |
Meningioma
|
0.800 |
Biomarker
|
disease |
BEFREE |
In two pairs of syngenous meningeal or meningioma cell lines with or without shRNA-mediated knockdown of NF2/Merlin a nearly complete loss of CD73 mRNA expression was observed after the knockdown (p ≤ 0.001).
|
29468444 |
2018 |
Meningioma
|
0.800 |
Biomarker
|
disease |
BEFREE |
The importance of NF2 (neurofibromin 2), TRAF7 (tumor necrosis factor [TNF] receptor-associated factor 7), KLF4 (Kruppel-like factor 4), AKT1, SMO (smoothened), PIK3CA (phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha), and POLR2 (RNA polymerase II subunit A) demonstrates that there are at least 6 distinct mutational classes of meningiomas.
|
29852774 |
2018 |
Meningioma
|
0.800 |
Biomarker
|
disease |
BEFREE |
We identified over 2000 proteins in comparative experiments between Merlin-deficient schwannoma and meningioma compared to human Schwann and meningeal cells respectively.
|
28126595 |
2017 |
Meningioma
|
0.800 |
Biomarker
|
disease |
BEFREE |
In addition, a strong overexpression of PrP<sup>C</sup> is observed in human Merlin-deficient mesothelioma cell line TRA and in human Merlin-deficient meningiomas.
|
28692055 |
2017 |
Meningioma
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
All VS and many meningiomas result from loss of the neurofibromatosis type 2 (NF2) gene product merlin, with ensuing PAK hyperactivation and increased cell proliferation/survival.
|
27755359 |
2017 |
Meningioma
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
Genetic alterations in grade I meningiomas include frequent deletions of chromosomal locus 22q12 and NF2 gene mutations and uncommon somatic SMARCB1 and SMARCE1gene mutations; In grade II meningiomas, chromosomal losses occur on 1p, 22q, 14q, 18q, 10, and 6q, and gains on 20q, 12q, 15q, 1q, 9q, and 17q; In grade III meningiomas, losses have been recognized on 6q, 10, and 14q and alterations of PTEN, CDKN2A and CDKN2B genes.
|
28527972 |
2017 |
Meningioma
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
In addition, these cell lines also harbored known meningioma driver mutations in neurofibromin 2 (NF2) and TNF receptor-associated factor 7 (TRAF7).
|
28552950 |
2017 |
Meningioma
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
MLPA screening identified NF2 gene deletions in 6 of 12 meningioma samples.
|
27871894 |
2017 |
Meningioma
|
0.800 |
Biomarker
|
disease |
BEFREE |
In all schwannomas, the majority of meningiomas and 1/3 of ependymomas Merlin loss is causative.
|
26549023 |
2016 |
Meningioma
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
Interestingly NF2 mutations and merlin inactivation also occur in spontaneous schwannomas and meningiomas, as well as other types of cancer including mesothelioma, glioma multiforme, breast, colorectal, skin, clear cell renal cell carcinoma, hepatic and prostate cancer.
|
25893302 |
2016 |
Meningioma
|
0.800 |
AlteredExpression
|
disease |
BEFREE |
Methylation-specific PCR verified that IL-1β induced methylation of the NF2 promoter and decreased NF2/merlin expression in meningioma/leptomeningeal cells.
|
26840621 |
2016 |
Meningioma
|
0.800 |
Biomarker
|
disease |
BEFREE |
Because group I p21-activated kinases (Paks) bind to and are inhibited by the NF2-encoded protein Merlin, we assessed the signaling and anti-tumor effects of three group-I specific Pak inhibitors - Frax597, 716 and 1036 - in NF2-/- meningiomas in vitro and in an orthotopic mouse model.
|
25596744 |
2015 |
Meningioma
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
Fluorescence in situ hybridization for chromosome 22 confirmed high allele loss involving the neurofibromin 2 gene locus, a finding typical in meningiomas.
|
25862935 |
2015 |
Meningioma
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
Deficiency of the tumour suppressor merlin leads to the development of schwannomas, meningiomas and ependymomas occurring spontaneously or as a part of the hereditary disease Neurofibromatosis type 2 (NF2).
|
25217104 |
2015 |
Meningioma
|
0.800 |
PosttranslationalModification
|
disease |
BEFREE |
These results suggest that cell density and ECM stiffness may contribute to the heterogeneous loss of merlin and increased nuclear YAP expression in human meningiomas.
|
26049897 |
2015 |
Meningioma
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
This study explores the status of the NF2 gene in pleuropulmonary meningothelial proliferations compared with CNS meningioma using interphase fluorescence in situ hybridization.
|
26291511 |
2015 |
Meningioma
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
A significant increase in risk of meningiomas is associated with neurofibromatosis type 2 (NF2) disease through mutation of the NF2 gene.
|
25857641 |
2015 |
Meningioma
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
Thus, monosomy 22, which is often associated with mutations of the NF2 gene, has emerged as the most frequent alteration of meningiomas; in addition, several other genes (e.g., AKT1, KLF4, TRAF7, SMO) and chromosomes have been found to be recurrently altered often in association with more complex karyotypes and involvement of multiple signaling pathways.
|
25965831 |
2015 |
Meningioma
|
0.800 |
Biomarker
|
disease |
BEFREE |
Moreover, Axl positively regulates the oncogene Yes-associated protein, which is known to be under merlin regulation in schwannoma and is involved in increased proliferation of merlin-deficient meningioma and mesothelioma.
|
23318455 |
2014 |