NF2, neurofibromin 2, 4771

N. diseases: 312; N. variants: 54
Disease: Neoplasm Metastasis ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis 		0.050 Biomarker phenotype BEFREE <i>CHL1</i> suppresses tumor growth and metastasis in nasopharyngeal carcinoma by repressing PI3K/AKT signaling pathway via interaction with Integrin β1 and Merlin. 31523184 2019
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis 		0.050 Biomarker phenotype BEFREE The NF2 gene encodes the tumor and metastasis suppressor protein Merlin. 29893810 2018
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis 		0.050 Biomarker phenotype BEFREE The mechanism of miR-146b-3p on cell metastasis was further determined by co-transfected with merlin (the protein product of NF2 gene). 30244634 2018
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis 		0.050 Biomarker phenotype BEFREE Our results indicate that the (Δ2-4)Merlin variant disrupts the normal function of Merlin and promotes tumour metastasis. 26443326 2015
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis 		0.050 Biomarker phenotype BEFREE However, the fact that inactivation of merlin in the mouse by targeted mutagenesis produces a variety of malignant tumors with a high rate of metastasis [33] suggests that merlin's suppression of tumor formation may involve different partners and pathways in different cell types and genetic backgrounds. 10214350 1999