Adult Meningioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Loss of PTPRJ/DEP-1 enhances NF2/Merlin-dependent meningioma development.
|
31715329 |
2020 |
Adult Meningioma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
To investigate neurofibromatosis type 2 (NF2) gene mutation at mRNA levels in sporadic orbitocranial meningioma and its association with progesterone receptor (PR) mRNA expression.
|
31024808 |
2019 |
Adult Meningioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Next-generation sequencing studies and increasingly sophisticated <i>NF2</i>-deletion-based <i>in vitro</i> and <i>in vivo</i> models have helped elucidate the consequences of merlin loss in meningioma pathogenesis.
|
31652973 |
2019 |
Adult Meningioma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The best defined of these syndromes is neurofibromatosis type 2, which is caused by a mutation in the NF2 gene and has a meningioma incidence of approximately 50%.
|
29660026 |
2018 |
Adult Meningioma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
This revealed that a frameshift deletion of the neurofibromin 2 gene likely drove formation of the meningioma.
|
29764516 |
2018 |
Adult Meningioma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The most frequent mutation among all meningioma grades occurred in the NF2 gene at 85% (11/13).
|
29846894 |
2018 |
Adult Meningioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
In two pairs of syngenous meningeal or meningioma cell lines with or without shRNA-mediated knockdown of NF2/Merlin a nearly complete loss of CD73 mRNA expression was observed after the knockdown (p ≤ 0.001).
|
29468444 |
2018 |
Adult Meningioma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In addition, these cell lines also harbored known meningioma driver mutations in neurofibromin 2 (NF2) and TNF receptor-associated factor 7 (TRAF7).
|
28552950 |
2017 |
Adult Meningioma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
MLPA screening identified NF2 gene deletions in 6 of 12 meningioma samples.
|
27871894 |
2017 |
Adult Meningioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
We identified over 2000 proteins in comparative experiments between Merlin-deficient schwannoma and meningioma compared to human Schwann and meningeal cells respectively.
|
28126595 |
2017 |
Adult Meningioma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Methylation-specific PCR verified that IL-1β induced methylation of the NF2 promoter and decreased NF2/merlin expression in meningioma/leptomeningeal cells.
|
26840621 |
2016 |
Adult Meningioma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Merlin expression and YAP phosphorylation were also affected by cell density in the IOMM-Lee and HKBMM human meningioma cell lines; nuclear localization of YAP was regulated by cell density and extracellular matrix (ECM) stiffness in IOMM-Lee cells.
|
26049897 |
2015 |
Adult Meningioma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
This study explores the status of the NF2 gene in pleuropulmonary meningothelial proliferations compared with CNS meningioma using interphase fluorescence in situ hybridization.
|
26291511 |
2015 |
Adult Meningioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Moreover, Axl positively regulates the oncogene Yes-associated protein, which is known to be under merlin regulation in schwannoma and is involved in increased proliferation of merlin-deficient meningioma and mesothelioma.
|
23318455 |
2014 |
Adult Meningioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Cell lines Ben-Men-1 (benign), IOMM-Lee and KT21 (malignant), and pairs of merlin-positive or -negative meningioma cells were used to assess sensitivity toward mTORC1 inhibitors in methyl-tetrazolium and bromodeoxyuridine (BrdUrd) assays.
|
23406776 |
2013 |
Adult Meningioma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Ring chromosome 22 and neurofibromatosis type II: proof of two-hit model for the loss of the NF2 gene in the development of meningioma.
|
21175598 |
2012 |
Adult Meningioma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Losses on 22q12.2, a region encoding the tumor suppressor gene merlin, represent the most common genetic alterations in early meningioma formation.
|
21529177 |
2011 |
Adult Meningioma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Transfection of genetic constructs of common NF2 missense mutations into NF2 gene-deficient meningioma cell lines revealed that merlin loss of function is due to a reduction in mutant protein half-life and increased protein degradation.
|
21383154 |
2011 |
Adult Meningioma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In our series, NF2 gene inactivation was an early and frequent event in progressing meningioma samples (73%).
|
20682713 |
2010 |
Adult Meningioma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
NF2/merlin is a novel negative regulator of mTOR complex 1, and activation of mTORC1 is associated with meningioma and schwannoma growth.
|
19451225 |
2009 |
Adult Meningioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
In our study, we investigated 149 meningiomas to determine whether there are additional tumor suppressor genes localized on chromosome 22q, apart from NF2, that might be involved in meningioma pathogenesis.
|
18474292 |
2008 |
Adult Meningioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
In addition, merlin loss in both meningioma cell lines and primary tumors resulted in increased YAP expression and nuclear localization.
|
18953429 |
2008 |
Adult Meningioma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Here we report on the clinical, radiological, and histological findings in an 8-year-old boy who was diagnosed with an isolated infratentorial meningioma and a novel splice site mutation in the NF2 gene.
|
17607601 |
2007 |
Adult Meningioma
|
0.100 |
PosttranslationalModification
|
disease |
BEFREE |
Analysis of 40 CpG sites distributed within 750 bp of the promoter region suggests that NF2 promoter methylation does not play a major role in meningioma development.
|
17222329 |
2007 |
Adult Meningioma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
When we compared the NF2 gene expression in the different meningioma grades we did not note a significant difference (P = 0.698) despite the tendency to decrease from grade I to grade III.
|
17319281 |
2007 |