Disease: Infant T Acute Lymphoblastic Leukemia ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C4288891
Disease: Infant T Acute Lymphoblastic Leukemia
Infant T Acute Lymphoblastic Leukemia 		0.010 Biomarker disease BEFREE Functional assessment revealed that the fusion had lower activity than wild-type NFATC3 <i>in vitro</i>, and T-ALLs with elevated <i>NFATC3-PLA2G15</i> levels had reduced transcription of canonical NFAT pathway genes <i>in vivo</i> Strikingly, high expression of the <i>NFATC3-PLA2G15</i> chimera correlated with aggressive disease biology in murine patient-derived T-ALL xenografts, and poor prognosis in human T-ALL patients.<i></i>. 29330284 2018