|
Cytomegalovirus Infections
|
0.010 |
Biomarker
|
group |
BEFREE |
NRF-1 regulates stress response genes that contain the antioxidant response element (ARE), and HCMV infection is associated with increased expression of many stress response genes when US27 is present.
|
30209167 |
2018 |
|
insulinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
In the present work, we studied the tumorigenicity of <i>Nfe2l1-</i>deficient insulinoma MIN6 cells (<i>Nfe2l1</i>-KD) and sensitivity to chemotherapy.
|
29203613 |
2018 |
|
Neoplasms
|
0.010 |
Biomarker
|
group |
BEFREE |
These data indicate that NFE2L1 could potentially play an important role in the carcinogenic process and impact chemosensitivity, at least within a subset of pancreatic endocrine tumors.
|
29203613 |
2018 |
|
Breast Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
The present study demonstrated a novel regulation loop between Nrf1α (the longest splicing form of Nrf1) and MRTF‑A that regulated the migration and invasion of breast cancer MDA‑MB‑231 cells.
|
30106093 |
2018 |
|
Tumor Cell Invasion
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
The present study demonstrated a novel regulation loop between Nrf1α (the longest splicing form of Nrf1) and MRTF‑A that regulated the migration and invasion of breast cancer MDA‑MB‑231 cells.
|
30106093 |
2018 |
|
Leukemia, T-Cell
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
HTLV-1 bZIP factor suppresses TDP1 expression through inhibition of NRF-1 in adult T-cell leukemia.
|
28993637 |
2017 |
|
Adult T-Cell Lymphoma/Leukemia
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
HTLV-1 bZIP factor suppresses TDP1 expression through inhibition of NRF-1 in adult T-cell leukemia.
|
28993637 |
2017 |
|
Alzheimer's Disease
|
0.010 |
Biomarker
|
disease |
BEFREE |
Further, Nfe2l1, Egr1 and Usf2 are sensitive to dietary factors and could be among links between dietary influences and genes in the AD etiology.
|
27050105 |
2016 |
|
Microphthalmos
|
0.010 |
Biomarker
|
disease |
BEFREE |
Of the melanocytic markers, HMB45 was most commonly expressed (16/16 positive, 100%), followed by microphthalmia transcription factor (11/12 positive, 92%), MelanA (14/16 positive, 88%), and S100 protein (2/10 positive, 20%).
|
24418852 |
2014 |
|
Parkinson Disease
|
0.010 |
Biomarker
|
disease |
BEFREE |
Although ZNF746, also known as Parkin-interacting substrate (PARIS), has been reported to suppress peroxisome proliferator-activated receptor γ coactivator-1α (PGC-1α) and its target gene NRF-1 leading to the neurodegeneration in Parkinson's disease, its function in tumorigenesis has yet to be investigated.
|
24145959 |
2014 |
|
Heart failure
|
0.010 |
Biomarker
|
disease |
BEFREE |
Taken together, these findings suggest that the mitochondrial degeneration engaged in the skeletal muscle atrophy and the heart failure in the NF90 Tg mice may be caused by NF90-induced posttranscriptional repression of transcription factors such as PGC-1 and NRF-1 for regulating nuclear-encoded genes relevant to mitochondrial function.
|
22912857 |
2012 |
|
Congestive heart failure
|
0.010 |
Biomarker
|
disease |
BEFREE |
Taken together, these findings suggest that the mitochondrial degeneration engaged in the skeletal muscle atrophy and the heart failure in the NF90 Tg mice may be caused by NF90-induced posttranscriptional repression of transcription factors such as PGC-1 and NRF-1 for regulating nuclear-encoded genes relevant to mitochondrial function.
|
22912857 |
2012 |
|
Fragile X Syndrome
|
0.010 |
Biomarker
|
disease |
BEFREE |
Interaction of the transcription factors USF1, USF2, and alpha -Pal/Nrf-1 with the FMR1 promoter. Implications for Fragile X mental retardation syndrome.
|
11058604 |
2001 |