|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.210 |
Biomarker
|
disease |
BEFREE |
Such dual control of the two pathways by NRF-1 place it as critical gene in the design of therapeutic modalities much needed to cure or better manage type 2 diabetes.
|
28263745 |
2017 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.210 |
Biomarker
|
disease |
MGD |
|
|
|
|
Liver neoplasms
|
0.200 |
Biomarker
|
group |
MGD |
|
|
|
|
Hepatoblastoma
|
0.200 |
Biomarker
|
disease |
MGD |
|
|
|
|
Malignant neoplasm of liver
|
0.200 |
Biomarker
|
disease |
MGD |
|
|
|
|
Liver carcinoma
|
0.200 |
Biomarker
|
disease |
MGD |
|
|
|
|
Hepatoblastoma Caused By Somatic Mutation
|
0.200 |
Biomarker
|
disease |
MGD |
|
|
|
|
Red Blood Cell Count measurement
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
|
30595370 |
2019 |
|
Obesity
|
0.020 |
Biomarker
|
disease |
BEFREE |
In conclusion, Nrf1 emerges as a novel guardian of brown adipocyte function, providing increased proteometabolic quality control for adapting to cold or to obesity.
|
29400713 |
2018 |
|
Carcinogenesis
|
0.020 |
Biomarker
|
phenotype |
BEFREE |
Overall, both <i>in vitro</i> and <i>in vivo</i> data from <i>Nfe2l1</i>-KD insulinoma cells provided evidence of a previously un-appreciated action of NFE2L1 in suppression of tumorigenesis.
|
29203613 |
2018 |
|
Obesity
|
0.020 |
Biomarker
|
disease |
BEFREE |
Special emphasis is placed on the effects of high fat diet (HFD) feeding on expression of nuclear-encoded mitochondrial genes (NEMGs) nuclear receptor factor 1 (NRF-1) and 2 (NRF-2) and peroxisome proliferator receptor gamma coactivator 1 alpha (PGC-1α) in the onset and progression of insulin resistance during obesity and how HFD-induced alterations in NEMG expression affect skeletal muscle mitochondrial adaptations in relation to beta oxidation of fatty acids.
|
28420087 |
2017 |
|
Carcinogenesis
|
0.020 |
Biomarker
|
phenotype |
BEFREE |
Although ZNF746, also known as Parkin-interacting substrate (PARIS), has been reported to suppress peroxisome proliferator-activated receptor γ coactivator-1α (PGC-1α) and its target gene NRF-1 leading to the neurodegeneration in Parkinson's disease, its function in tumorigenesis has yet to be investigated.
|
24145959 |
2014 |
|
Neuroblastoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
Novel genes FAM134C, C3orf10 and ENOX1 are regulated by NRF-1 and differentially regulate neurite outgrowth in neuroblastoma cells and hippocampal neurons.
|
23939472 |
2013 |
|
Central neuroblastoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
Novel genes FAM134C, C3orf10 and ENOX1 are regulated by NRF-1 and differentially regulate neurite outgrowth in neuroblastoma cells and hippocampal neurons.
|
23939472 |
2013 |
|
Childhood Neuroblastoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
Novel genes FAM134C, C3orf10 and ENOX1 are regulated by NRF-1 and differentially regulate neurite outgrowth in neuroblastoma cells and hippocampal neurons.
|
23939472 |
2013 |
|
Neuroblastoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
We found that stable or transient expression of full-length alpha-Pal/NRF-1 in human neuroblastoma IMR-32 cells significantly induced neurite outgrowth and increased the length of neurites both in medium containing 10% fetal bovine serum and in serum-free medium.
|
15992771 |
2005 |
|
Central neuroblastoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
We found that stable or transient expression of full-length alpha-Pal/NRF-1 in human neuroblastoma IMR-32 cells significantly induced neurite outgrowth and increased the length of neurites both in medium containing 10% fetal bovine serum and in serum-free medium.
|
15992771 |
2005 |
|
Childhood Neuroblastoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
We found that stable or transient expression of full-length alpha-Pal/NRF-1 in human neuroblastoma IMR-32 cells significantly induced neurite outgrowth and increased the length of neurites both in medium containing 10% fetal bovine serum and in serum-free medium.
|
15992771 |
2005 |
|
Encephalomyelitis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Decreased levels of constitutive proteasomes in experimental autoimmune encephalomyelitis may be caused by a combination of subunit displacement and reduced Nfe2l1 expression.
|
31709534 |
2020 |
|
Optic Atrophy 1
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Additionally, the hormone induced the expression of the nuclear respiratory factors 1 and 2 (Nrf-1 and Nrf-2), the mitochondrial transcription factors A (Tfam) and B2 (TFB2M), and the optic atrophy 1 (OPA1).
|
31676390 |
2020 |
|
Retinoblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Taken together, the results of the present study have uncovered a novel mechanism in which CXCR4 expression is regulated by Nrf‑1 in WERI‑Rb1 cells, thereby identifying novel potential targets for the treatment of RB, and providing evidence for the clinical application of TMP in adjuvant retinoblastoma therapy.
|
31322174 |
2019 |
|
B-Cell Lymphomas
|
0.010 |
AlteredExpression
|
group |
BEFREE |
Furthermore, overexpression of NRF‑1 increased the expression of B‑cell lymphoma‑2, hypoxia inducible factor‑1α and NRF‑2.
|
30628711 |
2019 |
|
Diffuse Large B-Cell Lymphoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Diagnostic biopsy samples of 76 patients with high-risk DLBCL were retrospectively stained with immunohistochemistry for Nrf1, Nrf2, Keap1 and Bach1, and correlated with clinical data and outcome.
|
30755497 |
2019 |
|
Pelvic Organ Prolapse
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
There was no significant difference in the TFAM(p = 0.377), NRF-1 and NRF-2 expression between the POP and non-POP groups (p = 0.647; p = 0.682).
|
31307745 |
2019 |
|
Malignant neoplasm of breast
|
0.010 |
Biomarker
|
disease |
BEFREE |
The present study demonstrated a novel regulation loop between Nrf1α (the longest splicing form of Nrf1) and MRTF‑A that regulated the migration and invasion of breast cancer MDA‑MB‑231 cells.
|
30106093 |
2018 |