Non-Small Cell Lung Carcinoma
|
0.600 |
CausalMutation
|
disease |
CGI |
|
|
|
Squamous cell carcinoma of the head and neck
|
0.440 |
CausalMutation
|
disease |
CGI |
|
|
|
IMMUNODEFICIENCY, DEVELOPMENTAL DELAY, AND HYPOHOMOCYSTEINEMIA
|
0.400 |
CausalMutation
|
disease |
CLINVAR |
|
|
|
Colorectal Carcinoma
|
0.200 |
GeneticVariation
|
disease |
CLINVAR |
|
|
|
Dwarfism
|
0.100 |
Biomarker
|
disease |
HPO |
|
|
|
Failure to Thrive
|
0.100 |
Biomarker
|
disease |
HPO |
|
|
|
Immunologic Deficiency Syndromes
|
0.100 |
Biomarker
|
group |
HPO |
|
|
|
Mild Mental Retardation
|
0.100 |
Biomarker
|
disease |
HPO |
|
|
|
Leukoencephalopathy
|
0.100 |
Biomarker
|
group |
HPO |
|
|
|
Short stature
|
0.100 |
Biomarker
|
phenotype |
HPO |
|
|
|
Delayed speech and language development
|
0.100 |
Biomarker
|
phenotype |
HPO |
|
|
|
Global developmental delay
|
0.100 |
Biomarker
|
disease |
HPO |
|
|
|
Recurrent skin infections
|
0.100 |
Biomarker
|
phenotype |
HPO |
|
|
|
Short Stature, CTCAE
|
0.100 |
Biomarker
|
phenotype |
HPO |
|
|
|
Recurrent respiratory infections
|
0.100 |
Biomarker
|
phenotype |
HPO |
|
|
|
Decreased antibody level in blood
|
0.100 |
Biomarker
|
phenotype |
HPO |
|
|
|
Neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
We report here that activation of the NQO1 ARE by tert-butylhydroquinone (tBHQ) is dependent on Nrf2 and not oxidative stress in IMR-32 human neuroblastoma cells.
|
11162512 |
2001 |
Central neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
We report here that activation of the NQO1 ARE by tert-butylhydroquinone (tBHQ) is dependent on Nrf2 and not oxidative stress in IMR-32 human neuroblastoma cells.
|
11162512 |
2001 |
Childhood Neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
We report here that activation of the NQO1 ARE by tert-butylhydroquinone (tBHQ) is dependent on Nrf2 and not oxidative stress in IMR-32 human neuroblastoma cells.
|
11162512 |
2001 |
Neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
These results together suggest that NO signals the transcriptional up-regulation of NQO1 and other detoxifying enzyme and protective genes through Nrf2 via the ARE to counteract NO-induced apoptosis of neuroblastoma cells.
|
14985350 |
2004 |
Central neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
These results together suggest that NO signals the transcriptional up-regulation of NQO1 and other detoxifying enzyme and protective genes through Nrf2 via the ARE to counteract NO-induced apoptosis of neuroblastoma cells.
|
14985350 |
2004 |
Childhood Neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
These results together suggest that NO signals the transcriptional up-regulation of NQO1 and other detoxifying enzyme and protective genes through Nrf2 via the ARE to counteract NO-induced apoptosis of neuroblastoma cells.
|
14985350 |
2004 |
Autoimmune Diseases
|
0.070 |
AlteredExpression
|
group |
BEFREE |
Activation of cytoprotective Nrf2/ARE-regulated genes can suppress inflammatory responses, whereas decreased expression of these genes results in autoimmune disease and enhanced inflammatory responses to oxidant insults.
|
15032691 |
2004 |
Malignant Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
A strategy for cancer prevention: stimulation of the Nrf2-ARE signaling pathway.
|
15252150 |
2004 |
Primary malignant neoplasm
|
0.100 |
Biomarker
|
group |
BEFREE |
A strategy for cancer prevention: stimulation of the Nrf2-ARE signaling pathway.
|
15252150 |
2004 |